Therapeutic potential of polyphenols in managing thalassemia: A comprehensive review

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dc.authorid0000-0002-2114-0964
dc.contributor.authorJamali, Sajjad
dc.contributor.authorJamali, Behzad
dc.contributor.authorGolabi, Marjan
dc.contributor.authorRostami, Mehdi
dc.contributor.authorYousefi, Zahra
dc.contributor.authorDabbaghipour, Reza
dc.contributor.authorEskandari, Nahid
dc.date.accessioned2026-02-03T12:00:20Z
dc.date.available2026-02-03T12:00:20Z
dc.date.issued2026
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: This study aims to review the potential effects of polyphenols on iron overload and inflammation in patients with beta-thalassemia. Materials and Methods: A literature search in electronic databases was carried out to identify studies exploring the therapeutic effects of flavonoids in thalassemia. Results: Patients with thalassemia suffer from excess iron in their bodies. In these patients, splenectomy is usually performed as an effective method to reduce the iron load and the need for blood transfusion. However, since the removal of the spleen in these patients to reduce the excess iron load is faced with serious side effects, it has been suggested to harness iron-chelators. Dietary polyphenols and polyphenol-rich products such as quercetin, curcumin, and silymarin prevent iron overload by reducing the serum levels of iron and ferritin. Polyphenols also reduce inflammation and oxidative stress by reducing tumor necrosis factor-alpha, C-reactive protein and malondialdehyde, and increasing total antioxidant capacity. Conclusion: The iron-chelating capacity of polyphenols and flavonoids which may have fewer side effects in patients with thalassemia, has garnered significant attention and holds a promise for therapeutic purposes.
dc.identifier.doi10.22038/ajp.2025.26013
dc.identifier.endpage65
dc.identifier.issn2228-7930
dc.identifier.issn2228-7949
dc.identifier.issue1
dc.identifier.startpage48
dc.identifier.urihttps://doi.org/10.22038/ajp.2025.26013
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34552
dc.identifier.volume16
dc.identifier.wosWOS:001644316200004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherMashhad Univ Med Sciences
dc.relation.ispartofAvicenna Journal of Phytomedicine
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectbeta-thalassemia
dc.subjectQuercetin
dc.subjectCurcumin
dc.subjectSilymarin
dc.subjectPolyphenolic compounds
dc.titleTherapeutic potential of polyphenols in managing thalassemia: A comprehensive review
dc.typeReview

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