Effect of 2-aminoethoxydiphenyl borate on ischemia-reperfusion injury in a rat ovary model

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dc.authoridÖnder, Gözde Özge / 0000-0002-0515-9286
dc.contributor.authorTaşkın, Mine Islimye
dc.contributor.authorHismiogullari, Adnan Adil
dc.contributor.authorYay, Arzu
dc.contributor.authorAdali, Ertan
dc.contributor.authorGüngör, Ayşenur Çakır
dc.contributor.authorKorkmaz, Gozde Ozge
dc.contributor.authorInceboz, Umit
dc.date.accessioned2025-01-27T20:41:02Z
dc.date.available2025-01-27T20:41:02Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: The aim of this study is to evaluate the effects of 2-aminoethoxydiphenyl borate (2-APB) as an antioxidant and analyze biochemical and histopathologic changes in experimental ischemia-reperfusion (I/R) injury in rat ovaries. Study design: Thirty female rats were utilized to create four groups. Group 1: I/R and 2-APB (2 mg/kg); Group 2: I/R and 2-APB (4 mg/kg); Group 3: I/R; Group 4: sham operation. Ovarian tissue and serum malondialdehyde, nitric oxide (NO) levels; ovarian tissue and serum total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) were determined. In ovarian tissue samples histopathologic examination, immunoflourescence staining by TUNEL method was studied. Results: Tissue TOS, serum TOS, and OSI levels were elevated in I/R group. After treatment with 2-APB, tissue and serum TOS levels and OSI levels were markedly decreased. There was a significant difference in terms of tissue and serum NO levels between the sham group and I/R group. Elevation in tissue NO and serum NO levels were decreased after treatment with 2-APB. TUNEL-positive cell number gradually decreased with dose of 2-APB in groups 1 and 2. Conclusion: Conservative treatment with 2-APB is beneficial for mitigation of I/R injury, and the ovarian protective effect of 2-APB appears to be mediated through its antiapopitotic and antioxidative effects. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
dc.identifier.doi10.1016/j.ejogrb.2014.03.049
dc.identifier.endpage79
dc.identifier.issn0301-2115
dc.identifier.issn1872-7654
dc.identifier.pmid24792541
dc.identifier.startpage74
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2014.03.049
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23983
dc.identifier.volume178
dc.identifier.wosWOS:000339036600015
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subject2-Aminoethoxydiphenyl borate (2-APB)
dc.subjectRat
dc.subjectAdnexal torsion
dc.subjectIschemia-reperfusion
dc.titleEffect of 2-aminoethoxydiphenyl borate on ischemia-reperfusion injury in a rat ovary model
dc.typeArticle

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