MONOCYTE-TO-HDL CHOLESTEROL RATIO AS A NEW PARAMETER OF SYSTEMIC INFLAMMATION AND DISEASE SEVERITY IN TREATMENT-RESISTANT CHRONIC SPONTANEOUS URTICARIA

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dc.authoridKAYA, OZGE/0000-0001-8062-1664
dc.contributor.authorKaya, Ozge
dc.contributor.authorMermutlu, Selda Isik
dc.date.accessioned2025-01-27T20:44:21Z
dc.date.available2025-01-27T20:44:21Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: Chronic spontaneous urticaria (CSU) is characterized by inflammation and increased oxidative stress in its pathogenesis. The study aims to evaluate new inflammatory markers indicating systemic inflammation in resistant CSU and to determine their relationship with disease activity. Material and Methods: The files of CSU patients and matched healthy volunteers were reviewed and compared in terms of demographics, medical history, clinical features, laboratory parameters, and new inflammatory markers [NLR:neutrophil-lymphocyte ratio, MLR: monocyte-lymphocyte ratio, MHR:monocyte-to-high-density lipoprotein cholesterol (HDL-C)]. Results: Sixty-one CSU patients and 50 healthy controls were evaluated (female: male ratio=1.9:1, mean age=43.97 +/- 14.88 years). The median erythrocyte sedimentation rate, C-reactive protein (CRP), white blood cell, monocyte count, and MHR were higher in the CSU group; in contrast, the mean HDL-C level was lower. The median NLR and MLR were also higher in the CSU group but were not statistically significant. There was a positive correlation between urticaria activity score 7 (UAS7) and MHR and a negative correlation between UAS 7 and HDL-C. MHR was positively correlated with MLR, CRP, and UAS7. Conclusion: MHR might serve as an indicator of inflammation intensity and predisposition to MS in CSU patients. It might also be used as an objective tool for evaluating disease severity and treatment response in CSU
dc.identifier.doi10.30621/jbachs.1210134
dc.identifier.endpage506
dc.identifier.issn2458-8938
dc.identifier.issn2564-7288
dc.identifier.issue1
dc.identifier.startpage501
dc.identifier.urihttps://doi.org/10.30621/jbachs.1210134
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24545
dc.identifier.volume7
dc.identifier.wosWOS:000929801200009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherDokuz Eylul Univ Inst Health Sciences
dc.relation.ispartofJournal of Basic and Clinical Health Sciences
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectChronic spontaneous urticaria
dc.subjectC-reactive protein
dc.subjectinflammation
dc.subjectmetabolic syndrome
dc.subjectmonocyte-to-HDL ratio
dc.titleMONOCYTE-TO-HDL CHOLESTEROL RATIO AS A NEW PARAMETER OF SYSTEMIC INFLAMMATION AND DISEASE SEVERITY IN TREATMENT-RESISTANT CHRONIC SPONTANEOUS URTICARIA
dc.typeArticle

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