Serum Ischemia-Modified Albumin Levels in Experimental Model of Acute Pancreatitis
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Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Coll Physicians & Surgeons Pakistan
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To establish whether the Ischemia-Modified Albumin (IMA), a new parameter of oxidative stress, has diagnostic role in experimental acute pancreatitis. Study Design: Randomized controlled trial. Place and Duration of Study: Experimental Animal Center, Canakkale Onsekiz Mart University, Canakkale, Turkey, from May to September 2013. Methodology: Sixteen Sprague-Dawley rats were randomly divided into two groups (n=8 each): Sham and AP groups. AP was induced by ligation of pancreatic duct. Serum IMA, amylase, lipase, AST, ALT and CRP were determined. The severity of pancreatitis was scored by a blinded pathologist under microscope. Results: Serum IMA levels in the AP group increased significantly compared with the control group (p < 0.05). There was also a strong positive correlation between amylase and IMA levels. Conclusion: The present study showed in a rodent model that serum IMA might serve as an additional marker to monitor inflammation during pancreatitis.
Açıklama
Anahtar Kelimeler
Amylase, Acute pancreatitis, Rodent, Ischemia-modified albumin
Kaynak
Jcpsp-Journal of The College of Physicians and Surgeons Pakistan
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
25
Sayı
6
