The effect of levosinnendan on myocardial ischemia reperfusion injury in streptozotocin-induced diabetic rats

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dc.authoridArslan, Mustafa/0000-0003-4882-5063
dc.contributor.authorKiraz, Hasan Ali
dc.contributor.authorPoyraz, Fatih
dc.contributor.authorKip, Gulay
dc.contributor.authorErdem, Ozlem
dc.contributor.authorAlkan, Metin
dc.contributor.authorArslan, Mustafa
dc.contributor.authorOzer, Abdullah
dc.date.accessioned2025-01-27T20:41:10Z
dc.date.available2025-01-27T20:41:10Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Ischemia/reperfusion (I/R) injury is an important cause of myocardial damage by means of oxidative, inflammatory, and apoptotic mechanisms. The aim of the present study was to examine the potential cardio protective effects of levosimendan in a diabetic rat model of myocardial I/R injury. Methods: A total of 18 streptozotocin-induced diabetic Wistar Albino rats (55 mg/kg) were randomly divided into three equal groups as follows: the diabetic I/R group (DIR) in which myocardial I/R was induced following left thoracotomy, by ligating the left anterior descending coronary artery for 60 min, followed by 2 h of reperfusion; the diabetic I/R levosimendan group (DIRL), which underwent I/R by the same method while taking levosimendan intraperitoneal 12 mu g kg(-1); and the diabetic control group (DC) which underwent sham operations without tightening of the coronary sutures. As a control group (C), six healthy age-matched Wistar Albino rats underwent sham operations similar to the DC group. Two hours after the operation, the rats were sacrificed and the myocardial tissue samples were examined by light microscopy for evidence of myonecrosis and inflammatory cell infiltration. Results: Myonecrosis findings were significantly different among groups (p = 0.008). Myonecrosis was more pronounced in the DIR group compared with the C, DC, and DIRL groups (p = 0.001, p = 0.007 and p = 0.037, respectively). Similarly, the degree of inflammatory cell infiltration showed significant difference among groups (p < 0.0001). Compared with C, DC, and DIRL groups, the inflammatory cell infiltration was significantly higher among the DIR group (p < 0.0001, p < 0.0001, and p = 0.020, respectively). Also, myocardial tissue edema was significantly different among groups (p = 0.006). The light microscopic myocardial tissue edema levels were significantly higher in the DIR group than the C, DC, and DIRL groups (p = 0.001, p = 0.037, and p = 0.014, respectively). Conclusion: Taken together, our data indicate that levosimendan may be helpful in reducing myocardial necrosis, myocardial inflammation, and myocardial tissue edema resulting from ischemia reperfusion injury.
dc.identifier.doi10.3402/Ijm.v10.29269
dc.identifier.issn1993-2820
dc.identifier.issn1819-6357
dc.identifier.pmid26649830
dc.identifier.urihttps://doi.org/10.3402/Ijm.v10.29269
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24048
dc.identifier.volume10
dc.identifier.wosWOS:000366137200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCo-Action Publishing
dc.relation.ispartofLibyan Journal of Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectischemia-reperfusion
dc.subjectlevosimendan
dc.subjectmyonecrosis
dc.subjectinflammatory cell infiltration
dc.subjectdiabetic rat
dc.titleThe effect of levosinnendan on myocardial ischemia reperfusion injury in streptozotocin-induced diabetic rats
dc.typeArticle

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