The frequency of toll-like receptor 4 gene polymorphism in ankylosing spondylitis and its relationship between disease activity

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dc.contributor.authorSılan, Fatma
dc.contributor.authorÖzdemir, Öztürk
dc.contributor.authorZateri, Coşkun
dc.contributor.authorSavaş, Yılmaz
dc.contributor.authorAkbal, Ayla
dc.contributor.authorReşorlu, Hatice
dc.contributor.authorSargın, Betül
dc.date.accessioned2025-01-27T20:01:37Z
dc.date.available2025-01-27T20:01:37Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective. We aimed to evaluate the frequency of toll-like receptor 4 (TLR4) gene polymorphism and itsrelationship between disease activity in patients with ankylosing spondylitis (AS). Methods. Forty-one ASpatients (25 male/16 female) fullfilling the 1984 Modified New York Criteria and 41 healthy controls (25male/16 female) were included in this study. Disease activity of the AS patients was assesed by Bath AnkylosingSpondylitis Disease Activity Index (BASDAI). The TLR4 gene polymorphism of AS patients and healthycontrols were analyzed by Real-Time Polymerase Chain Reaction (PCR) System. Results. Three (7.3%) patientswith AS had TLR4 gene polymorphism compared with healthy controls (0/41; 0%). Two of these patients hadheterozygous mutation and one had homozygous mutation. Significant correlation was not found betweenTLR4 gene polymorphism and BASDAI score (p > 0.05). Conclusions. In our study, TLR4 gene polymorphismwas higher in patients with AS compared with control group. But, this polymorphism was not associated withdisease activity, erythrocyte sedimentation rate and C-reactive protein levels
dc.identifier.endpage111
dc.identifier.issn2149-3189
dc.identifier.issue2
dc.identifier.startpage106
dc.identifier.trdizinid273169
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/273169
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20157
dc.identifier.volume4
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofThe European Research Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectGenetik ve Kalıtım
dc.subjectRomatoloji
dc.subjectİmmünoloji
dc.titleThe frequency of toll-like receptor 4 gene polymorphism in ankylosing spondylitis and its relationship between disease activity
dc.typeArticle

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