Pre-conception folic acid intake and attention deficit and hyperactivity disorder in children

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dc.contributor.authorUzun, Mehmet Erdem
dc.contributor.authorKaymaz, Nazan
dc.contributor.authorAylanç, Hakan
dc.contributor.authorGökten, Emel Sarı
dc.contributor.authorŞirin, Hande
dc.contributor.authorŞehitoğlu, M.Hilal
dc.date.accessioned2025-01-27T19:22:45Z
dc.date.available2025-01-27T19:22:45Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjectives: Attention Deficit Hyperactivity Disorder (ADHD) is a common disorder in children. It is thought to occur due to the interaction of many genetic and environmental factors during early  development. Many studies have been conducted to investigate the etiology of ADHD. Some have investigated neurobiology, and others have investigated malnutrition and trace element deficiency. To investigate the effect of folic acid intake during the pre-conception period in terms of ADHD development. Methods: Five hundred and ninety-eight participants, 246 children with ADHD, and 352 healthy controls were enrolled. A questionnaire was completed, including socio-demographic information and the use of folic acid and other supplements such as a multivitamin, iron, and omega 3 during pregnancy. Data were examined to determine associations with ADHD. Mann-Whitney U tests for continuous variables, Pearson’s chi-square, and Fisher’s exact tests for categorical variables were used to compare groups. Results: The use of folic acid during pre-pregnancy among mothers who had a child with ADHD was 13% and this was 31% in the control group (p < 0.001). There was no statistically significant difference between the groups’ use of folic acid in pregnancy (p = 0.617). Other situations related to ADHD were advanced maternal age (p < 0.001 for both groups), abnormal double screening test results in pregnancy (27% vs. 5%, p < 0.001) and omega 3 use in pregnancy (p < 0.001). Conclusions: The use of folic acid before and during pregnancy is important for neurological development. However, there is little data on use before pregnancy in the literature. This study shows that folic acid taken before pregnancy may prevent ADHD in childhood. The present study recommends folic acid usage in planned pregnancy to prevent ADHD in the child. 
dc.identifier.doi10.18621/eurj.1129774
dc.identifier.endpage327
dc.identifier.issn2149-3189
dc.identifier.issue2
dc.identifier.startpage322
dc.identifier.trdizinid1158536
dc.identifier.urihttps://doi.org/10.18621/eurj.1129774
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1158536
dc.identifier.urihttps://hdl.handle.net/20.500.12428/15214
dc.identifier.volume9
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofThe European Research Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectBeslenme ve Diyetetik
dc.subjectPediatri
dc.subjectPsikoloji
dc.titlePre-conception folic acid intake and attention deficit and hyperactivity disorder in children
dc.typeArticle

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