The Effect of Agomelatine on the Nociceptive System

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dc.authoridERSAN, Yusuf/0000-0002-0065-3656
dc.contributor.authorKivrak, Yuksel
dc.contributor.authorKarademir, Basaran
dc.contributor.authorAygun, Hayati
dc.contributor.authorErsan, Yusuf
dc.contributor.authorAri, Mustafa
dc.contributor.authorKaraahmet, Elif
dc.contributor.authorYagci, Ibrahim
dc.date.accessioned2025-01-27T20:38:55Z
dc.date.available2025-01-27T20:38:55Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective:The aim of the study was to study the effects of agomelatine, an antidepressant, on the nociceptive. system. Methods: Twenty four male Swiss albino mice (four months old and 28.8 +/- 1.18 g average weight) were randomly divided into three groups, which were equal in numbers; Group A and B were the experimental groups and group C was the control group. Group A was given 12.5 mg/kg of agomelatine, Group B was given 25 mg/kg agomelatine and Group C was given physiological saline via intraperitoneal injection. To evaluate the nociceptive effects, by using the hot plate method (50 degrees C), pain threshold values of the control and agomelatine groups were recorded as the 30th and 60th minute findings. Results: According to the pain threshold results, the datafor the two agomelatine groups were found to be higher than control group at both time points. In 30th minute measurements, between Group B and the other groups, significant differences were observed (p=0.007). In addition, significance in the interaction between time and group was observed (p=0.036). Conclusions: The results of the study suggest that agomelatine might have analgesic efficacy on the nociceptive system in mice.
dc.identifier.doi10.5455/bcp.20130925022745
dc.identifier.endpage225
dc.identifier.issn1017-7833
dc.identifier.issue3
dc.identifier.startpage220
dc.identifier.urihttps://doi.org/10.5455/bcp.20130925022745
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23800
dc.identifier.volume24
dc.identifier.wosWOS:000345108400004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherKure Iletisim Grubu A S
dc.relation.ispartofKlinik Psikofarmakoloji Bulteni-Bulletin of Clinical Psychopharmacology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectagomelatine
dc.subjectanalgesia
dc.subjectantidepressant
dc.subjecthyperalgesia
dc.subjectmelatonin
dc.subjectnociceptive system
dc.subjectpain
dc.titleThe Effect of Agomelatine on the Nociceptive System
dc.typeArticle

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