Synthesis and antimicrobial activites of 1,2,4-oxadiazin-5-one, 6-one and 5-thiones

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dc.contributor.authorÖlmez, Nevin Arıkan
dc.contributor.authorSümengen, Doğan
dc.contributor.authorDülger, Başaran
dc.date.accessioned2025-01-27T20:01:15Z
dc.date.available2025-01-27T20:01:15Z
dc.date.issued2008
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractN-Substituted pyridine carboxamide oximes (2) were obtained from the reactions of pyridine hydroxamic acid chloride hydrochlorides (1) with primary amines. The reactions of carboxamide oximes with chloroacetyl chloride in the presence of triethylamine gave the corresponding 3,4-disubstituted- 1,2,4-oxadiazin-5-ones (3), which on treatment with P2S5 gave in moderate yielded the corresponding 3,4-disubstituted-1,2,4-oxadiazin-5-thiones (4). The reaction of pyridine carboxamide oximes with $\\alpha$- aminoacid ester led to the formation of 3,5-disubstituted-1,2,4-oxadiazin-6-ones (5) in moderate yields. The structures of the prepared compound were evaluated by spectroscopy. Some of the representatives of 3,4-disubstituted-1,2,4-oxadiazin-5-ones, thiones, and 3,5-disubstituted-1,2,4-oxadiazin-6-ones were screened for antibacterial activity using disc diffusion. It was found that all the tested compounds have good antimicrobial activities.
dc.identifier.endpage155
dc.identifier.issn1300-0527
dc.identifier.issn1303-6130
dc.identifier.issue2
dc.identifier.startpage147
dc.identifier.trdizinid75551
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/75551
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20019
dc.identifier.volume32
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTurkish Journal of Chemistry
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectKimya
dc.subjectOrganik
dc.subjectFarmakoloji ve Eczacılık
dc.titleSynthesis and antimicrobial activites of 1,2,4-oxadiazin-5-one, 6-one and 5-thiones
dc.typeArticle

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