Assessment of serum hepcidin levels in patients with non-ST elevationmyocardial infarction
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Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Hepcidin is an acute-phase reactant produced in the liver displaying intrinsic antimicrobial activity. There are few studies abouthepcidin considered to be acute and chronic inflammatory marker in acute coronary syndromes patients. We investigated in our study wheth-er the level of hepcidin has increased in the acute phase of non-ST elevation myocardial infarction patients (NSTEMI) known as acute inflam-matory aggravation of chronic atherosclerotic process.Methods: Seventy patients with NSTEMI and twenty healthy people were recruited as controls in this observational cross-sectional study.Serum hepcidin levels were determined by ELISA, and troponin levels were measured by standard laboratory methods. Levels of hepcidin andtroponin were measured at admission and 6 hours later. Mean values of continuous variables were compared between groups using theStudent t-test or Mann-Whitney U test, according to whether normally distributed or not, as tested by the Kolmogorov-Smirnov test. Serumtroponin and hepcidin levels measured at admission and after 6th hours were compared using paired t-test.Results: Hepcidin level was similar between NSTEMI and controls at admission (24.55±32.13, 23.67±33.62 ng/mL, p>0.05, respectively). Also, serum hepcidinlevels did not change significantly from baseline in blood samples taken after 6 hour from admission in NSTEMI patients (24.55±32.13 ng/mL, 29.75±31.48ng/mL, p=0.62, respectively). However, serum troponin levels were increased significantly compared to baseline (0.29±3.56, 2.92±7.2 ng/mL, p<0.01).Conclusion: Our findings suggest that hepcidin could not be use as a marker of myocardial necrosis in acute phase such as troponin in patientswith NSTEMI.
Açıklama
Anahtar Kelimeler
Tıbbi Araştırmalar Deneysel, Kalp ve Kalp Damar Sistemi
Kaynak
Anadolu Kardiyoloji Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
14
Sayı
6
