The protective effect of MCP-1-2518 A>G promoter polymorphism in Turkish chronic renal failure patients requiring long-term hemodialysis

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dc.authoridbagci, binnur/0000-0003-1323-3359
dc.authoridBagci, Gokhan/0000-0003-4554-2391
dc.contributor.authorBagci, Binnur
dc.contributor.authorBagci, Gokhan
dc.contributor.authorCandan, Ferhan
dc.contributor.authorÖzdemir, Öztürk
dc.contributor.authorSezgin, Ilhan
dc.date.accessioned2025-01-27T20:45:46Z
dc.date.available2025-01-27T20:45:46Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractMonocyte chemoattractant protein-1 (MCP-1) plays a major role in the pathogenesis and progression of different types of human renal disease. Therefore, in this study, we aimed to investigate the effect of MCP-1 gene -2518 A > G promoter polymorphism in chronic renal failure (CRF) patients requiring long-term hemodialysis. The study population consisted of 201 adult CRF patients requiring long-term hemodialysis and 194 healthy controls. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used for genotyping of MCP-1 -2518 A > G polymorphism in the CRF patients and healthy controls. There were statistically significant differences in terms of genotypic (chi (2) = 12.69, p = 0.02) and allelic (chi (2) = 5.72, p = 0.02) frequencies of MCP-1 -2518 A > G between CRF patients and control subjects. According to our results, in the patient group MCP-1 -2518 AA genotype frequency was significantly higher than that of control group. On the other hand, heterozygous AG genotype frequency in the control group was significantly higher than that of the study group. Three different main disease subgroups of CRF (hypertension, diabetes mellitus, and atherosclerosis) patients were also evaluated, and significant associations were found between hypertension (genotype: chi (2) = 9.28, p = 0.01; allele: chi (2) = 6.00, p = 0.01), atherosclerosis (genotype: chi (2) = 5.37, p = 0.02; allele: chi (2) = 4.13, p = 0.04), and distributions of MCP-1 -2518 A > G genotypes and alleles. However, no significant association was found between diabetes mellitus and distributions of MCP-1 -2518 A > G genotype and allele frequencies (genotype: chi (2) = 2.37, p = 0.3; allele: chi (2) = 1.88, p = 0.17). Current data show that MCP-1 -2518 AA genotype may cause susceptibility to CRF, while G allele may have a protective effect against development of CRF. In addition, MCP-1 -2518 AA genotype seems to associate with CRF originated from hypertension and atherosclerosis in our study population.
dc.identifier.doi10.1007/s11255-015-0922-3
dc.identifier.endpage556
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue3
dc.identifier.pmid25655256
dc.identifier.startpage551
dc.identifier.urihttps://doi.org/10.1007/s11255-015-0922-3
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24713
dc.identifier.volume47
dc.identifier.wosWOS:000350362400019
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Urology and Nephrology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectMCP-1
dc.subjectChronic renal failure
dc.subjectPolymorphism
dc.subjectHypertension
dc.subjectDiabetes mellitus
dc.subjectAtherosclerosis
dc.titleThe protective effect of MCP-1-2518 A>G promoter polymorphism in Turkish chronic renal failure patients requiring long-term hemodialysis
dc.typeArticle

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