Radioprotective effects of nigella sativa oil against oxidative stress in liver tissue of rats exposed to total head irradiation

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dc.contributor.authorCikman, Oztekin
dc.contributor.authorOzkan, Adile
dc.contributor.authorAras, Adem Bozkurt
dc.contributor.authorSoylemez, Omer
dc.contributor.authorAlkis, Hilal
dc.contributor.authorTaysi, Seyithan
dc.contributor.authorKaraayvaz, Muammer
dc.date.accessioned2025-01-27T18:59:13Z
dc.date.available2025-01-27T18:59:13Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Many cancer patients treated with radiotherapy suffer severe side effects during and after their treatment. The aim of this study was to investigate the effects of irradiation and the addition of Nigella sativa oil (NSO) on the oxidant/antioxidant system in the liver tissue of irradiated rats. Methods: A total of 24 Sprague-Dawley rats were randomly distributed into three groups of equal numbers. The control group received neither NSO nor irradiation but received 1-ml saline orally. The irradiation group (IR) received total head 5 gray (Gy) of gamma irradiation as a single dose, plus 1-ml saline orally. The IR plus NSO group received both total head 5 Gy of gamma irradiation as a single dose and 1 g/kg/day NSO orally through an orogastric tube starting one hour before irradiation and continuing for 10 days. Results: While liver tissue total oxidant status (TOS), lipid hydroperoxide (LOOH) level, and oxidative stress index (OSI) were significantly increased in the IR group compared to the control group, total antioxidant status (TAS), sulfhydryl (-SH) levels, and PON activity were significantly decreased. Cp activity in the IR plus NSO and IR groups was higher than in the control group. ARYL activity in the IR plus NSO supplemented group was higher than that in other groups. Conclusions: NSO reduces oxidative stress markers and has antioxidant effects, which also augments the antioxidant capacity in the liver tissue of rats. © 2014 Informa Healthcare USA, Inc.
dc.identifier.doi10.3109/08941939.2014.898811
dc.identifier.endpage266
dc.identifier.issn0894-1939
dc.identifier.issue5
dc.identifier.pmid24679182
dc.identifier.scopus2-s2.0-84907029095
dc.identifier.scopusqualityQ1
dc.identifier.startpage262
dc.identifier.urihttps://doi.org/10.3109/08941939.2014.898811
dc.identifier.urihttps://hdl.handle.net/20.500.12428/13195
dc.identifier.volume27
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInforma Healthcare
dc.relation.ispartofJournal of Investigative Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250125
dc.subjectFree radicals; Irradiation; Nigella sativa oil; Oxidative stress index; Total antioxidant status; Total oxidant status
dc.titleRadioprotective effects of nigella sativa oil against oxidative stress in liver tissue of rats exposed to total head irradiation
dc.typeArticle

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