Serum ischemia-modified albumin levels in experimental model of acute pancreatitis

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dc.contributor.authorTopaloglu, Naci
dc.contributor.authorKucuk, Adem
dc.contributor.authorTekin, Mustafa
dc.contributor.authorYildirim, Sule
dc.contributor.authorErbas, Mesut
dc.contributor.authorKiraz, Hasan Ali
dc.contributor.authorCakir, Dilek Ulker
dc.date.accessioned2025-01-27T19:02:40Z
dc.date.available2025-01-27T19:02:40Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: To establish whether the Ischemia-Modified Albumin (IMA), a new parameter of oxidative stress, has diagnostic role in experimental acute pancreatitis. Study Design: Randomized controlled trial. Place and Duration of Study: Experimental Animal Center, Çanakkale Onsekiz Mart University, çanakkale, Turkey, from May to September 2013. Methodology: Sixteen Sprague-Dawley rats were randomly divided into two groups (n=8 each): Sham and AP groups. AP was induced by ligation of pancreatic duct. Serum IMA, amylase, lipase, AST, ALT and CRP were determined. The severity of pancreatitis was scored by a blinded pathologist under microscope. Results: Serum IMA levels in the AP group increased significantly compared with the control group (p < 0.05). There was also a strong positive correlation between amylase and IMA levels. Conclusion: The present study showed in a rodent model that serum IMA might serve as an additional marker to monitor inflammation during pancreatitis.
dc.identifier.endpage398
dc.identifier.issn1022-386X
dc.identifier.issue6
dc.identifier.pmid26100988
dc.identifier.scopus2-s2.0-84930814351
dc.identifier.scopusqualityQ2
dc.identifier.startpage395
dc.identifier.urihttps://hdl.handle.net/20.500.12428/13622
dc.identifier.volume25
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCollege of Physicians and Surgeons Pakistan
dc.relation.ispartofJournal of the College of Physicians and Surgeons Pakistan
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250125
dc.subjectAcute pancreatitis; Amylase; Ischemia-modified albumin; Rodent
dc.titleSerum ischemia-modified albumin levels in experimental model of acute pancreatitis
dc.typeArticle

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