Carbohydrate-Derived Tailorable Interfaces: Recent Advances and Applications
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Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Singapore
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Carbohydrates from simple sugars to complex polysaccharides comprise a large number of biomolecules that are readily available from replenishable sources. They perform crucial biological functions through diverse interplays with proteins and lipids on the basis of specific interactions such as modulation of immune response, cellular signaling, growth, and molecular recognition events. Due to their ability to reversibly bind through hydrophobic interactions and hydrogen bonding, carbohydrates have been exploited as intriguing substrates for the design of responsive nanovehicles and therefore hold great potential for a myriad of biomedical applications. Furthermore, functional groups that exist on carbohydrates such as amino-, hydroxyl-, and acetate groups provide facile modification sites for the prepared nanostructures and render additional functionalities, e.g., carbohydrate particles with fine-tuned particle size, shape, and surface properties. In addition to these advantages, carbohydrates are biologically safe, mostly biocompatible, degradable, and have stealth characteristics along with their affinity to specific cellular elements, which enables the active targeting of the corresponding nanocarriers and the design of tailor-made, efficient, and long circulatory carrier systems. This chapter provides a brief overview of carbohydrates on the basis of structural and functional properties and highlights the cutting-edge advancements on carbohydrate-based polymeric materials in biomedical applications with a particular focus placed on the applications of polysaccharide-based micro_/nanohydrogels in nanomedicine. © Springer Nature Singapore Pte Ltd. 2021.
Açıklama
Anahtar Kelimeler
Biopolymers; Carbohydrates; Hydrogel; Long circulatory; Microgel; Nanogel; Nanoparticles; Polysaccharides; Protein repellent; Stealth; Targeting
Kaynak
Nano Medicine and Nano Safety: Recent Trends and Clinical Evidences
WoS Q Değeri
Scopus Q Değeri
N/A
