Synthesis and Characterization of Thiazole Compounds in the Presence of Various Reagents, Catalysts and Solvents

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dc.contributor.authorBerber, Nurcan
dc.date.accessioned2025-01-27T19:20:28Z
dc.date.available2025-01-27T19:20:28Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe reaction medium plays a key role in organic synthesis and pharmaceutical research. There are many opinions on choosing the best condition, including cost and environmental implications, but the main requirement is that they have the necessary interaction with solvents to cause dissolution, precipitation, stabilization, or instability. For this purpose, in this article synthesis of the thiazole ring was made under various reaction conditions. So new compounds 2-(isoquinolin-5-ylimino)-3-phenylthiazolidin-4-one (1), (4-amino-3-phenylthiazol-2(3H)-ylidene) isoquinolin-5-amine (2), (4-amino-3-phenylthiazol-2(3H)-ylidene) isoquinolin-5-amine (3) were synthesized from the reaction between thiourea derivative and monochloroacetic acid, diethyloxalate and chloro acetonitrile. For this synthesizes were created in various reaction conditions, using different bases (sodium acetate/sodyum etoksit/ triethylamine or pyridine) and solvents (1,4-dioxane, toluene, acetic acid, ethanol, tetrahydrofuran, dimethyl formamide). At the end of these reactions, the best efficiency was obtained with the one-pot reaction using THF/DMF, Et3N. The structures of all novel compounds reported herein were established using FT-IR, 1H NMR, and 13C NMR spectra as well as elemental analysis technique.
dc.identifier.doi10.16984/saufenbilder.950016
dc.identifier.endpage767
dc.identifier.issn1301-4048
dc.identifier.issn2147-835X
dc.identifier.issue4
dc.identifier.startpage757
dc.identifier.trdizinid1119890
dc.identifier.urihttps://doi.org/10.16984/saufenbilder.950016
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1119890
dc.identifier.urihttps://hdl.handle.net/20.500.12428/14885
dc.identifier.volume26
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofSakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectKimya
dc.subjectTıbbi
dc.titleSynthesis and Characterization of Thiazole Compounds in the Presence of Various Reagents, Catalysts and Solvents
dc.typeArticle

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