Synthetic Cannabinoid Use is Associated with Higher Systemic Inflammatory Indices than Cannabis Use in Adolescents

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dc.contributor.authorTunagur, Mustafa Tolga
dc.contributor.authorKurt Tunagur, Elif Merve
dc.date.accessioned2026-02-03T12:03:00Z
dc.date.available2026-02-03T12:03:00Z
dc.date.issued2026
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe growing use of cannabis and synthetic cannabinoids (SCs) among adolescents raises concerns about their distinct physiological effects. This retrospective case-control study evaluated systemic inflammatory indices in 88 adolescents with cannabinoid use disorder (CUD) (mean age = 16.42 +/- 1.06 years; 51.1% male)-subdivided into Cannabis-CUD, SC-CUD, and Dual-CUD groups-compared with 50 healthy controls (mean age = 16.14 +/- 0.80 years; 40% male). & Idot;nflammatory indices, neutrophil-, basophil-, monocyte-, and platelet-to-lymphocyte ratios (NLR, BLR, MLR, PLR, dNLR, and NLPR), and systemic inflammatory indices (SII, SIRI, and AISI), were analyzed using ANOVA and ROC curve analysis. NLR, dNLR, BLR, SII (all p < .001), and NLPR, PLR, SIRI, AISI (p < .05) were significantly higher in the CUD group compared to healthy controls. Compared to controls, SC-CUD showed significantly higher inflammatory indices (p < 0.001 for NLR, BLR, and SII), while Dual-CUD showed moderate elevations (p = 0.009, p = 0.027, and p = 0.003 for NLR, BLR, and SII, respectively). For cannabis-CUD, BLR was the only marker that significantly differed from controls (p = 0.019). ROC analysis identified BLR (AUC = 0.72), SII (AUC = 0.71), and NLR (AUC = 0.70) as the strongest predictors of CUD. These findings highlight the comparatively higher inflammatory indices observed in the synthetic cannabinoid groups and suggest that blood-based indices may help identify adolescents at elevated physiological risk associated with cannabinoid use.
dc.identifier.doi10.1007/s11469-025-01622-y
dc.identifier.issn1557-1874
dc.identifier.issn1557-1882
dc.identifier.urihttps://doi.org/10.1007/s11469-025-01622-y
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34925
dc.identifier.wosWOS:001662991900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Journal of Mental Health and Addiction
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectCannabis use disorder
dc.subjectSynthetic cannabinoids
dc.subjectInflammation
dc.subjectAdolescent
dc.subjectNeutrophil-to-lymphocyte ratio
dc.subjectSystemic inflammation index
dc.subjectBiomarkers
dc.titleSynthetic Cannabinoid Use is Associated with Higher Systemic Inflammatory Indices than Cannabis Use in Adolescents
dc.typeArticle

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