The effect of gender on disease activity and clinical characteristics in patients with axial psoriatic arthritis
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Oxford University Press
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: In this study, we aimed to evaluate the effect of gender on clinical findings, disease activity, functional status and quality of life in patients with axial involvement in Turkey.
Methods: Patients with PsA who met the CASPAR classification criteria were enrolled consequently in
this cohort. Turkish League Against Rheumatism (TLAR)-Network was formed with the participation of
25 centres. The demographic variables, fatigue, diagnostic delay, the beginning of peripheral arthritis,
enthesitis, dactylitis and spine involvement, inflammatory low back pain, BASFI, HAQ, HAQ-s, visual
analogue scale-pain (VAS-pain), anxiety, depression and disease activity parameters (ESR, DAS28,
BASDAI) were recorded. Axial involvement was assessed according to clinical and radiological data
according to modified New York (MNYC) or Assessment of SpondyloArthritis international Society
(ASAS) criteria.
Results: A total of 1018 patients with PsA were included in this study. Of the 373 patients with axial
involvement, 150 were male (40.2%) and 223 (59.8%) were female. Spondylitis was detected in 14,7%
of men and 21,9% of women in all patients. Pain score (VAS) (p < .002), fatigue (p < .001), ESR
(p < .001), DAS28 (p < .001), BASDAI score (p < .001), PsAQoL (p < .001), HAQ score (p < ,01), HAQ-S
score (p < .001), anxiety (p < .001), depression (p < .024), FACIT (p < .001) and FiRST (p < .001) scores
were statistically significantly worse in women than males with axial PsA. However, quality of life was
better (p < .001) and PASI score (p < .005) were statistically worse in male patients than in female
patients with axial involvement.
Conclusion: This study has shown that the burden of disease in axial PsA has significant difference
between genders. Disease activity, physical disability, functional limitation, depression and anxiety
scores were higher in female patients, while quality of life were better and PASI score were higher in
male patients. Therefore, we suggest that new strategies should be developed for more effective treatment of axial PsA in female patients.
Açıklama
Anahtar Kelimeler
Psoriatic arthritis, Axial involvement, Gender, Quality of life, Risk factors
Kaynak
Modern Rheumatology
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
31
Sayı
4
Künye
Nas, K., Kiliç, E., Tekeoğlu, İ., Keskin, Y., Çevik, R., Sargin, B., … Tuncer, T. (2020). The effect of gender on disease activity and clinical characteristics in patients with axial psoriatic arthritis. Modern Rheumatology, 31(4), 869–874. https://doi.org/10.1080/14397595.2020.1812870
