Protective effect of metformin against lithium-induced cerebral neurotoxicity in rats

Basit Öğe Kaydı
dc.contributor.authorMalçok, Ümit Ali
dc.contributor.authorŞehitoğlu, Müşerref Hilal
dc.contributor.authorBuyuk, Basak
dc.contributor.authorTaş, Halil İbrahim
dc.date.accessioned2025-01-27T19:57:47Z
dc.date.available2025-01-27T19:57:47Z
dc.date.issued2021
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractNeurotoxic effects are seen in patients using lithium regardless of dose. The neuroprotective activity of metformin used in the treatment of patients with type 2 diabetes mellitus is known. In this study, the protective efficacy of metformin against the neurotoxic effects of lithium was investigated. Neurotoxicity was induced by administering high dose oral lithium (40 mmol/kg) to rats for two weeks. Four groups were formed, with 6 rats in each group. OSI indices were calculated by measuring serum TAS and TOS levels. TAS, TOS, OSI, Gpx ADAM10, and ADAM17 levels were measured in the brain tissue. The neuroprotective activity of metformin was examined histopathologically by calculating the pyknosis scores, vacuolization, and interstitial edema in the hippocampus and cortex tissues. When lithium and metformin were given together, serum levels of TAS, TOS, and OSI were lower than that of the Lithium group (p<0.001), whereas the TAS level in the brain tissue was higher than that of the lithium group (p<0.05). With the concomitant administration of lithium and metformin, ADAM10 levels decreased (p<0.05), whereas ADAM17 and Gpx levels increased (p>0.05). In histopathological evaluation, pyknosis, interstitial edema, and vacuolization scores of the hippocampus and cortex regions increased with lithium alone but were low when lithium was given together with metformin. Levels of the antioxidant molecules Gpx and TAS decreased with lithium, and ADAM10 and ADAM17 proteins, which indicate the strength of intercellular bonding, increased by administering metformin. In conclusion, the toxic effect of lithium on brain tissue was reduced by metformin.
dc.identifier.endpage355
dc.identifier.issn2147-0634
dc.identifier.issue2
dc.identifier.startpage350
dc.identifier.trdizinid489091
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/489091
dc.identifier.urihttps://hdl.handle.net/20.500.12428/19734
dc.identifier.volume10
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofMedicine Science
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectEndokrinoloji ve Metabolizma
dc.subjectNörolojik Bilimler
dc.subjectBiyokimya ve Moleküler Biyoloji
dc.titleProtective effect of metformin against lithium-induced cerebral neurotoxicity in rats
dc.typeArticle

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