The Levels of Serum Mg, NO and IMA in Chronic Kidney Disease

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dc.contributor.authorBakırdöğen, Serkan
dc.contributor.authorDemir, Sabire Ceren
dc.contributor.authorTürkon, Hakan
dc.contributor.authorÇakir, Dilek Ülker
dc.contributor.authorTok, Burak
dc.date.accessioned2025-01-27T20:01:41Z
dc.date.available2025-01-27T20:01:41Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractNTRODUCTION: In chronic kidney disease (CKD) patients, serum levels of ischemia-modified albumin (IMA), are found to be higher compared to the normal population. As oxidative stress increases, nitric oxide (NO) production reduces linked to endothelial dysfunction. Magnesium (Mg) increases NO production by endothelium. The aim of the study was to compare serum IMA, NO, and Mg levels in patients with CKD (stage 1-4).METHODS: The study included 29 CKD patients with stage 1-4. Additionally, a control group comprised 40 healthy volunteers. Serum IMA, NO, and Mg testing was performed in both groups. Serum Mg was analyzed with the colorimetric method, IMA was analyzed with the rapid colorimetric method, while NO was analyzed with ELISA. Statistical significance was accepted as p < 0.05.RESULTS: Serum IMA levels were significantly higher in the patient group than in the control group. (p=0.023), while there were no differences between the groups in terms of serum NO and Mg (p>0.05). In the patient group a statistically significant and positive correlation was identified betweenserum IMA and NO (p=0.023, r=0.421). There was no statistically significant correlation between serum IMA and Mg (p=0.96). There was a statistically significant and negative correlation between serum NO and Mg (p=0.02, r=-0.43).DISCUSSION AND CONCLUSION:Examination of the serum NO and Mg levels in CKD patients (stage 1-4) was not found to be beneficial to predict oxidative stress.
dc.identifier.endpage26
dc.identifier.issn2147-0758
dc.identifier.issue3
dc.identifier.startpage22
dc.identifier.trdizinid412935
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/412935
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20174
dc.identifier.volume9
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofKocaeli Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectGenel ve Dahili Tıp
dc.subjectPatoloji
dc.subjectHematoloji
dc.subjectTıbbi Laboratuar Teknolojisi
dc.titleThe Levels of Serum Mg, NO and IMA in Chronic Kidney Disease
dc.typeArticle

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