EFFECTS OF BORIC ACID IN AN EXPERIMENTAL RAT MODEL OF HEPATIC ISCHEMIA-REPERFUSION INJURY

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dc.authoridSUNAY, FATMA BAHAR/0000-0002-2231-7979
dc.contributor.authorBasbug, Murat
dc.contributor.authorYildar, Murat
dc.contributor.authorYaman, Ismail
dc.contributor.authorOzkan, Omer Faruk
dc.contributor.authorAksit, Hasan
dc.contributor.authorCavdar, Faruk
dc.contributor.authorSunay, Fatma Bahar
dc.date.accessioned2025-01-27T20:16:51Z
dc.date.available2025-01-27T20:16:51Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction: Hepatic ischemia-reperfusion injury can cause serious damages and affect distant organs. Boric acid is a antioxidant agent in ischemia/reperfusion injury. The aim of this study was to investigate the effects of boric acid in a rat model of hepatic ischemia-reperfusion injury. Material and methods: 30 rats were divided into three groups: sham, ischemia reperfusion and ischemia-reperfusion+boric acid. The sham group underwent only the surgical stress procedure. In the ischemia-reperfusion group, liver ischemia was induced by clamping the hepatic pedicle for 45 minute, followed by reperfusion for 1 hour. In the ischemia-reperfusion +boric acid group, the therapeutic agent boric acid was administered intraperitoneally, 10 minute before clamping the hepatic pedicle. Serum levels of malondialdehyde, superoxide dismutase, glutathione, total antioxidant capacity, tumor necrosis factor-alpha, interleukin-6, aspartate aminotransferase, alanine aminotransferase, Gamma-glutamyl transferase were determined. Liver tissues were taken for histopathological examination, DNA fragmentation, and TUNEL staining to determine the apoptotic index. Results: Boric acid moderately reduced serum levels of malondialdehyde, tumor necrosis factor-alpha, interleukin-6. aspartate aminotransferase, gamma-glutamyl transferase in the ischemia-reperfusion injury group. Superoxide dismutase and alanine aminotransferase levels were decreased significantly in the boric acid-administered group (P < 0.05). The histopathological injury scores and the rate of apoptosis were significantly higher in the ischemia-reperfusion group; these injuries were reduced by boric acid administration. Conclusion: Our results demonstrate that boric acid decreases lipid peroxidation and enhances the antioxidant defense mechanism. This study showed that boric acid might protect against ischemia-reperfusion injury in this rat model.
dc.description.sponsorshipScientific and Technological Research Council of Turkey [113S445]
dc.description.sponsorshipThis study was supported by The Scientific and Technological Research Council of Turkey (Project no: 113S445)
dc.identifier.endpage1073
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue5
dc.identifier.startpage1067
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21413
dc.identifier.volume31
dc.identifier.wosWOS:000372137700023
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherCarbone Editore
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectHepatic Ischemia Reperfusion
dc.subjectBoric Acid
dc.titleEFFECTS OF BORIC ACID IN AN EXPERIMENTAL RAT MODEL OF HEPATIC ISCHEMIA-REPERFUSION INJURY
dc.typeArticle

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