Premenstrual Dysphoric Disorder and Affective Temperament in Patients with Polycystic Ovary Syndrome

INTRODUCTION: This study aimed to evaluate the affectivetemperaments of women with Polycystic Ovary Syndrome(PCOS), to assess its comorbidity with PremenstrualDysphoric Disorder (PMDD) and compare with HealthyControls (HC).METHODS: A total of 20 women with PCOS and 20 HC wereincluded in this study. Hospital Anxiety and Depression Scale(HADS) and Temperament Evaluation of Memphis, Pisa, Parisand San Diego-Autoquestionnaire version (TEMPS-A) wereapplied to all participants. The Diagnoses of PMDD and otherpsychiatric disorders were made by staff psychiatristsinterviewing all participants using DSM-5 diagnostic criteria.RESULTS: The comorbidity of PMDS in patients with PCOSwas 30% (n=6), while it was 15% (n=3) in the HC group.PMDS proportions did not differ significantly between groups.Patients with PCOS had higher major depression (25%, n=5)and anxiety disorders (20%, n=4) compared with HCs, butonly anxiety disorders were significantly higher in PCOS thanthe HC group (p=0.03).DISCUSSION and CONCLUSION: Patients with PCOS mayhave more comorbidity risk of PMDD, which is a mooddisorder according to DSM–5, and associated with menstrualcycles. Considering and treating PMDD and other psychiatricconditions may increase the quality of life and functionality ofwomen with PCOS.