Fetal Vegf Genotype is More Important for Abortion Risk than Mother Genotype

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dc.contributor.authorYalcintepe, Sinem Atik
dc.contributor.authorSilan, Fatma
dc.contributor.authorHacivelioglu, Servet Ozden
dc.contributor.authorUludag, Ahmet
dc.contributor.authorCosar, Emine
dc.contributor.authorOzdemir, Ozturk
dc.date.accessioned2025-01-27T21:23:42Z
dc.date.available2025-01-27T21:23:42Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractVEGF gene has been reported to be related with many diseases and recurrent pregnancy loss in various studies. Concerning the role of VEGF polymorphisms in pregnancy losses, generally mothers genotypes have been analyzed. To evaluate the association between VEGF A +405G/C (rs2010963), -460T/C (rs833061), +936C/T (rs3025039) and - 2578A/C (rs699947) polymorphisms and spontaneous abortion, we studied the genotypes of spontaneously aborted fetuses, their mothers and healthy controls. 23 spontaneously aborted fetal materials, 22 mothers who had these abortions and 86 healthy controls were included in this study. rs2010963, rs833061, rs3025039 and rs699947 polymorphisms were analyzed by Real Time PCR technique after genomic DNA isolation from all subjects. The frequencies of VEGF A rs2010963 GG genotype and rs2010963 G allele were higher in fetuses compared both with mothers and healthy controls. VEGF A rs3025039 TT genotype and rs3025039 T allele frequencies were higher in fetuses comparing with mothers. VEGF A rs833061 CT and TT genotypes frequencies were higher in fetuses comparing with mothers. We ascertained that VEGF A rs2010963, rs833061 and rs3025039 are the risk factors for spontaneous abortion in fetal genotypes comparing with their mothers and healthy controls.
dc.description.sponsorshipScientific Research Projects [2012-029]; Scientific Research Projects Unit of Canakkale On Sekiz Mart University
dc.description.sponsorshipThis study was supported by a funding from Scientific Research Projects (2012-029) and a permission from Human Researchs Ethics Committee was taken from Canakkale Onsekiz Mart University.This research was supported by a funding from Scientific Research Projects Unit of Canakkale On Sekiz Mart University. Authors thank Sengul TURUNZ for her technical support.
dc.identifier.endpage94
dc.identifier.issn2251-9637
dc.identifier.issn2251-9645
dc.identifier.issue2
dc.identifier.pmid25035858
dc.identifier.startpage88
dc.identifier.urihttps://hdl.handle.net/20.500.12428/29271
dc.identifier.volume3
dc.identifier.wosWOS:000218814900004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCellular & Molecular Biology Research Center
dc.relation.ispartofInternational Journal of Molecular and Cellular Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectSpontaneous abortion
dc.subjectVEGF
dc.subjectfetus
dc.subjectsingle nucleotide polymorphism
dc.titleFetal Vegf Genotype is More Important for Abortion Risk than Mother Genotype
dc.typeArticle

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