Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats

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dc.authoridBayir, Yasin/0000-0003-3562-6727
dc.authoridALBAYRAK, ABDULMECIT/0000-0002-1062-1965
dc.authoridCADIRCI, ELIF/0000-0003-0836-7205
dc.authoridTOKTAY, Erdem/0000-0002-0715-2707
dc.authoridYayla, Muhammed/0000-0002-0659-3084
dc.contributor.authorCadirci, Elif
dc.contributor.authorHalici, Zekai
dc.contributor.authorYayla, Muhammed
dc.contributor.authorToktay, Erdem
dc.contributor.authorBayir, Yasin
dc.contributor.authorKarakus, Emre
dc.contributor.authorTopcu, Atilla
dc.date.accessioned2025-01-27T20:38:47Z
dc.date.available2025-01-27T20:38:47Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThis study investigated possible role of U-II and its receptor expression in inflammation by using UTR agonist and antagonist in carrageenan induced acute inflammation. Rats were divided into 5 groups as (1) Healthy control, (2) Carrageenan control, (3) Carrageenan +Indomethacin 20 mg/kg, orally, (4) Carrageenan +AC7954 (U-II receptor agonist, intraperitoneally) 30 mg/kg and (5) Carrageenan +SB657510 (UTR antagonist, intraperitoneally) 30 mg/kg. 1 h after drug administration, carrageenan was injected. At the 3rd hour after carrageenan injection, agonist produced no effect while antagonist 63% anti-inflammatory effect respectively. UTR and UT-II expression increased in carrageenan induced paw tissue. Antagonist administration prevented the decrease in an antioxidant system and also capable to decrease TNF-alpha and IL-6 mRNA expressions. This study showed the role of urotensin II receptors in the physiopathogenesis of acute inflammatory response that underlying many diseases accompanied by inflammation. (C) 2016 Elsevier Inc. All rights reserved.
dc.description.sponsorshipTurkish Academy of Sciences (TUBA) The Young Scientists Award Programme (GEBIP) [EC/TUBAGEBIP20135]; Ataturk University Medical Research Council [2013/233]
dc.description.sponsorshipThis work was supported by Turkish Academy of Sciences (TUBA) The Young Scientists Award Programme (GEBIP) with project number EC/TUBAGEBIP20135 and by the Ataturk University Medical Research Council (grant number 2013/233).
dc.identifier.doi10.1016/j.peptides.2016.05.006
dc.identifier.endpage43
dc.identifier.issn0196-9781
dc.identifier.issn1873-5169
dc.identifier.pmid27208703
dc.identifier.startpage35
dc.identifier.urihttps://doi.org/10.1016/j.peptides.2016.05.006
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23749
dc.identifier.volume82
dc.identifier.wosWOS:000380748700005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofPeptides
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectUrotensin II
dc.subjectInflammation
dc.subjectSB657510
dc.subjectRats
dc.subjectTNF-Alpha
dc.titleBlocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats
dc.typeArticle

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