Improved bone formation in osteoporotic rabbits with the bone morphogenetic protein-2 (rhBMP-2) coated titanium screws which were coated by using plasma polymerization technique

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dc.contributor.authorGulsen, Salih
dc.contributor.authorCokeliler, Dilek
dc.contributor.authorGoktas, Hilal
dc.contributor.authorKucukturhan, Aysu
dc.contributor.authorOzcil, Bilgehan
dc.contributor.authorCaner, Hakan
dc.date.accessioned2025-01-27T19:00:24Z
dc.date.available2025-01-27T19:00:24Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractDelaying of bone fusion in osteoporotic patients underwent spinal stabilization surgery leads to screw loosening, and this causes pseudoarticulation, mobility and fibrosis at vertebral segments. To prevent these complications, the screws coated with recombinant bone morphogenetic protein-2 (rhBMP-2) could be used. To verify this hypothesis, we coated 5 Titanium screws with rhBMP-2 using plasma polymerization method, and also used 10 uncoated screws for making comparison between coated and uncoated screws in different groups. And 15 skeletally mature white New Zealand female rabbits were assigned into three different groups: Group 1(N = 5): No osteoporosis induction and insertion of uncoated Titanium screw into right sacrum of each rabbit in group 1; group 2 (N = 5): Osteoporosis induction and insertion of uncoated Titanium screw into right sacrum of each rabbit in group 2; group 3 (N = 5) rhBMP-2 coated Titanium screw inserted into right sacrum of each rabbit in group 3. In summary, using of these coated screws provides new bone formation, but causes less fibrosis and less inflammation than uncoated screws at the interface between the coated screw and bone. Then the plasma polymerization technique provides controlled releasing of rhBMP-2 from the screw to the bone tissue in osteoporotic rabbits. © 2014 Gulsen et al.
dc.identifier.doi10.3889/oamjms.2014.031
dc.identifier.endpage208
dc.identifier.issn1857-5749
dc.identifier.issue2
dc.identifier.scopus2-s2.0-84902493771
dc.identifier.scopusqualityN/A
dc.identifier.startpage198
dc.identifier.urihttps://doi.org/10.3889/oamjms.2014.031
dc.identifier.urihttps://hdl.handle.net/20.500.12428/13305
dc.identifier.volume7
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherInstitute of Immunobiology and Human Genetics
dc.relation.ispartofMacedonian Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250125
dc.subjectBone morphogenic protein; Osteoporosis; Screw; Titanium
dc.titleImproved bone formation in osteoporotic rabbits with the bone morphogenetic protein-2 (rhBMP-2) coated titanium screws which were coated by using plasma polymerization technique
dc.typeArticle

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