Comparison of Commonly Used Methods for Testing Interaction Effect in Time-Course Microarray Experiments

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dc.contributor.authorTran, Nhu Quynh
dc.contributor.authorKoçak, Mehmet
dc.contributor.authorMendeş, Mehmet
dc.date.accessioned2025-01-27T19:37:03Z
dc.date.available2025-01-27T19:37:03Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: The objective of this study is to compare performances of maSigPro, BATS,Repeated Measures ANOVA (RM-ANOVA), and Classical RM-ANOVA, which are commonlyused methods, for testing interaction effect in time-course microarray experiments. Material andMethods: We generated random time-course gene expression profiles from multivariate normaldistribution based on two different covariance structures, three different time-series lengths, andtwo different profile types. Results: The results suggested that the BATS and the maSigPro aregenerally more superior methods to the ANOVA-based methods in terms of sensitivity and specificitymeasures. In general, the BATS was more appropriate for medium and especially for longterm data sets while maSigPro was appropriate almost for all experimental conditions. On theother hand, the ANOVA-based methods had a good performance especially for the short-termtime-course profiles. Conclusion: Thus, we concluded that length of time-course measurementand profile types are two major factors affecting the performances of these methods.
dc.identifier.doi10.5336/biostatic.2016-53627
dc.identifier.endpage44
dc.identifier.issn1308-7894
dc.identifier.issn2146-8877
dc.identifier.issue1
dc.identifier.startpage35
dc.identifier.trdizinid293386
dc.identifier.urihttps://doi.org/10.5336/biostatic.2016-53627
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/293386
dc.identifier.urihttps://hdl.handle.net/20.500.12428/17100
dc.identifier.volume9
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTürkiye Klinikleri Biyoistatistik Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectBiyoloji
dc.subjectİstatistik ve Olasılık
dc.titleComparison of Commonly Used Methods for Testing Interaction Effect in Time-Course Microarray Experiments
dc.typeArticle

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