Decellularized tumor matrices as biomimetic cancer niche: a new perspective on cancer research and therapy

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dc.authorid0000-0003-3445-1814
dc.authorid0000-0002-9471-9918
dc.authorid0000-0002-6442-7842
dc.contributor.authorOzudogru, Eren
dc.contributor.authorKurt, Tugce
dc.contributor.authorArslan, Yavuz Emre
dc.date.accessioned2026-02-03T12:02:21Z
dc.date.available2026-02-03T12:02:21Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractCancer is among the major causes of mortality, responsible for approximately 15% of all deaths worldwide. Despite remarkable progress in modern medicine, it remains a significant global health challenge. Nevertheless, conventional therapies such as chemotherapy and radiotherapy target healthy and malignant tissues, leading to adverse side effects, including hair loss, fatigue, and nausea, which significantly reduce patients' quality of life. Even more critically, the therapeutic response varies from patient to patient, which reduces the effectiveness of treatment. Therefore, cancer tissue engineering has evolved as a novel interdisciplinary field, aiming to develop structures that mimic the tumor microenvironment to elucidate cancer development mechanisms and devise effective treatment methods. However, producing a fully synthetic biosimilar matrix by assembling all individual ECM components remains unfeasible due to the heterogeneity and complex structure of tumor tissues, as well as the necessity of highly advanced micro- and nanoengineering techniques. Consequently, decellularization techniques have recently been applied to cancer tissues to produce biomimetic tumor models. In this review, we provided a comprehensive overview of the extracellular matrix (ECM) architecture and its role in tumor progression. We also discussed the structural differences between normal and malignant tissues. We briefly reviewed decellularization techniques and analytical approaches for ECM characterization. Emphasizing the cutting-edge research, we categorized developments into three groups: decellularized tumor-derived ECM (dT-ECM), hydrogels, and bioinks. Subsequently, we critically assessed the benefits, limitations, and potential future developments of dT-ECM-based strategies. Finally, we envision that tumor tissue engineering will provide preventive treatment approaches by developing patient-specific predictive and personalized cancer models through integrating advanced biomaterials with artificial intelligence and machine learning.
dc.identifier.doi10.1088/1748-605X/ae187d
dc.identifier.issn1748-6041
dc.identifier.issn1748-605X
dc.identifier.issue6
dc.identifier.pmid41151155
dc.identifier.urihttps://doi.org/10.1088/1748-605X/ae187d
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34710
dc.identifier.volume20
dc.identifier.wosWOS:001609524600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherIop Publishing Ltd
dc.relation.ispartofBiomedical Materials
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectdecellularization
dc.subjectextracellular matrix
dc.subjecttumor microenvironment
dc.subjectdecellularized tumor
dc.subjectcancer tissue engineering
dc.titleDecellularized tumor matrices as biomimetic cancer niche: a new perspective on cancer research and therapy
dc.typeReview

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