The effects of intravenous oxytocin and methylergonovine administration on QT interval in rabbits

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dc.contributor.authorUzun, Metehan
dc.contributor.authorKaraca, Mehmet
dc.contributor.authorTopçu, Birkan
dc.contributor.authorKurt, Yunus
dc.date.accessioned2025-01-27T19:02:34Z
dc.date.available2025-01-27T19:02:34Z
dc.date.issued2009
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe aim of this study was to evaluate changes in heart rate (HR), QT, and QTc values in conscious female New Zeland rabbits which intravenously received oxytocin (OXT), methylergonovine (ME) and OXT plus ME at different dosages. Animals were divided in to 9 equal groups; Group 1 (n=6, received 0.5 U OXT per animal), group 2 (n=6, received 1 U OXT per animal), group 3 (n=6, received 3 U OXT per animal), group 4 (n=6, 0.1 mg ME per animal), group 5 (n=6, received 0.2 mg ME per animal), group 6 (n=6, received 0.3 mg ME per animal), group 7 (n=6, received 0.5 U OXT + 0.1 mg ME per animal), group 8 (n=6, received 1 U OXT + 0.2 mg ME per animal) and group 9 (n=6, received 3 U OXT + 0.3 mg ME per animal). Electrocardiographical recording were taken from all animals before injection and then at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 14, 16, 18 and 20. minutes of each drug administration. The HR, QT and QTc values were estimated from ECG recording. The HR values decreased in OXT and OXT plus ME injected groups (P<0.001). In these groups prolongation of QT and QTc intervals were observed after drug injection during the 1-3 minutes (P<0.001). There were not determined significant changes of all observed parameters in ME injected groups. In conclusion, it should be taken into consideration by the physicians QT prolongation and short-term and serious bradycardia due to OXT application. The results of the study also suggest that ME may be safer than OXT in terms of HR and QT intervals.
dc.identifier.doi10.9775/kvfd.2008.120-a
dc.identifier.endpage356
dc.identifier.issn1300-6045
dc.identifier.issue3
dc.identifier.scopus2-s2.0-70349139574
dc.identifier.scopusqualityQ3
dc.identifier.startpage351
dc.identifier.urihttps://doi.org/10.9775/kvfd.2008.120-a
dc.identifier.urihttps://hdl.handle.net/20.500.12428/13574
dc.identifier.volume15
dc.indekslendigikaynakScopus
dc.language.isotr
dc.publisherKAFKAS UNIVERSITY
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250125
dc.subjectECG; Methylergonovine; Oxytocin; QT; Rabbit
dc.titleThe effects of intravenous oxytocin and methylergonovine administration on QT interval in rabbits
dc.title.alternativeTavşanlarda Damar İçi Oksitosin ve Metil Ergonovin Enjeksiyonunun QT Süresi Üzerine Etkileri
dc.typeArticle

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