Endocrine disruptors and children's health

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dc.contributor.authorKarakiliç, Ersen
dc.contributor.authorDo?an, Durmuş
dc.date.accessioned2026-02-03T11:53:33Z
dc.date.available2026-02-03T11:53:33Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractEndocrine-disrupting chemicals (EDCs) are environmental contaminants that disrupt hormonal regulation by mimicking, inhibiting, or modifying endocrine signaling pathways. EDCs are commonly present in plastics, pesticides, industrial byproducts, and personal care products and pose substantial health risks, particularly to vulnerable groups such as infants and children. Early-life exposure is especially concerning due to the developing detoxification systems, the immaturity of the blood–brain barrier, and the ongoing organ differentiation, making these periods highly susceptible to EDCs’ harmful effects. Moreover, exposure during critical developmental periods, such as sex differentiation and neurodevelopment, can lead to significant long-term developmental impairments that persist into later life. Perinatal and childhood exposure to EDCs has been linked to various adverse health outcomes, including neurodevelopmental delays, impairments in reproductive health, obesity, type 2 diabetes, thyroid dysfunction, and even a heightened risk of certain malignancies. These effects are mediated through various mechanisms, including direct modulation of hormone receptors, disruption of genetic regulation, and interference with endocrine feedback systems. Alterations in endocrine signaling, particularly disruptions in thyroid hormone homeostasis, may also indirectly impair cognitive development, increasing the risk of attention disorders and intellectual impairment. Although regulatory measures to reduce EDC exposure are crucial, current restrictions remain insufficient. Moreover, as new EDCs emerge, ongoing research is essential to understand their risks and develop effective strategies to minimize their potential harm. Protecting future generations requires a proactive approach that combines public health awareness, strong regulations, and ongoing scientific research. This review highlights the potential risks of EDCs exposure in children and highlights the significance of multidisciplinary research and policy efforts. © TÜBİTAK.
dc.description.sponsorshipEuropean Commission, EC
dc.identifier.doi10.55730/1300-0144.6129
dc.identifier.endpage1680
dc.identifier.issn1300-0144
dc.identifier.issue7 Special Issue 1
dc.identifier.pmid41488246
dc.identifier.scopus2-s2.0-105026638744
dc.identifier.scopusqualityQ2
dc.identifier.startpage1671
dc.identifier.urihttps://doi.org/10.55730/1300-0144.6129
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34227
dc.identifier.volume55
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTUBITAK
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20260130
dc.subjectchild development disorders
dc.subjectchild health
dc.subjectEndocrine disruptors
dc.subjectobesity
dc.subjectpuberty
dc.subjectthyroid
dc.titleEndocrine disruptors and children's health
dc.typeReview

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