Protective effects of ursodeoxycholic acid in experimental corrosive esophagitis injury in rats

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dc.authoridYildirim, Sule/0000-0002-1815-808X
dc.contributor.authorKucuk, Adem
dc.contributor.authorTopaloglu, Naci
dc.contributor.authorYildirim, Sule
dc.contributor.authorTekin, Mustafa
dc.contributor.authorErbas, Mesut
dc.contributor.authorKiraz, Hasan Ali
dc.contributor.authorErdem, Havva
dc.date.accessioned2025-01-27T20:27:00Z
dc.date.available2025-01-27T20:27:00Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAccidental caustic ingestions are serious medical problems especially in childhood. Various treatment modalities are being used for the complications of caustic injuries such as stricture formation. The aim of this study is to establish whether ursodeoxycholic acid (UDCA) has protective effects on experimental corrosive esophagitis in rats. Twenty four Wistar-albino rats, weighing 220-240 g, were used in the study. Experimental animals were divided in three groups randomly: UDCA treatment group (Group 7; n:8), control group (Group K n: 8) and sham group (Group S, n: 8). In group T and S corrosive esophagitis was induced. UDCA (5 mg/kg) was performed to the group T for 10 days orally. All animals were sacrificed at the end of procedures and histopathological changes in esophageal tissue were scored by a single investigator who was blind to the groups. In group T inflammation was present in two rats, muscularis mucosa injury in two rats, grade I collagen deposition in six rats and grade 2 in two rats. In comparison with group S these were statistically significant (p value was 0.003, 0.003 and 0.015, respectively). UDCA has protective effect in experimental corrosive esophagitis.
dc.identifier.endpage86
dc.identifier.issn0003-469X
dc.identifier.issn2239-253X
dc.identifier.issue1
dc.identifier.pmid28447968
dc.identifier.startpage82
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22536
dc.identifier.volume88
dc.identifier.wosWOS:000398426800016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherEdizioni Luigi Pozzi
dc.relation.ispartofAnnali Italiani Di Chirurgia
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCorrosive esophagitis
dc.subjectRat
dc.subjectStricture
dc.subjectUrsodeoxycholic acid
dc.titleProtective effects of ursodeoxycholic acid in experimental corrosive esophagitis injury in rats
dc.typeArticle

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