Organic-inorganic biohybrid films from wool-keratin/jellyfish-collagen/silica/boron via sol-gel reactions for soft tissue engineering applications

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dc.contributor.authorYildiz, Safiye Nur
dc.contributor.authorSezgin Arslan, Tugba
dc.contributor.authorArslan, Yavuz Emre
dc.date.accessioned2025-01-27T18:56:01Z
dc.date.available2025-01-27T18:56:01Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractTherapeutic angiogenesis is pivotal in creating effective tissue-engineered constructs that deliver nutrients and oxygen to surrounding cells. Hence, biomaterials that promote angiogenesis can enhance the efficacy of various medical treatments, encompassing tissue engineering, wound healing, and drug delivery systems. Considering these, we propose a rapid method for producing composite silicon-boron-wool keratin/jellyfish collagen (Si-B-WK/JFC) inorganic-organic biohybrid films using sol-gel reactions. In this approach, reactive tetraethyl orthosilicate and boric acid (pKa ? 9.24) were used as silicon and boron sources, respectively, and a solid-state gel was formed through the condensation reaction of these reactive groups with the keratin/collagen mixture. Once the resulting gel was thoroughly suspended in water, the films were prepared by a casting/solvent evaporation methodology. The fabricated hybrid films were characterized structurally and mechanically. In addition, angiogenic characteristics were determined by the in ovo chick chorioallantoic membrane assay, which revealed an increased vascular network within the Si-B-WK/JFC biohybrid films. In conclusion, it is believed that Si-B-WK/JFC biohybrid films with mechanical and pro-angiogenic properties have the potential to be possessed in soft tissue engineering applications, especially wound healing. © 2024 The Author(s). Published by IOP Publishing Ltd.
dc.description.sponsorshipÇanakkale Onsekiz Mart Üniversitesi, ÇOMÜ, (FYL-2022-3983); ÇOBILTUM; Çanakkale Onsekiz Mart University Science and Technology Application and Research Center
dc.identifier.doi10.1088/1748-605X/ad2557
dc.identifier.issn1748-6041
dc.identifier.issue2
dc.identifier.pmid38306684
dc.identifier.scopus2-s2.0-85185006692
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1088/1748-605X/ad2557
dc.identifier.urihttps://hdl.handle.net/20.500.12428/12816
dc.identifier.volume19
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInstitute of Physics
dc.relation.ispartofBiomedical Materials (Bristol)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250125
dc.subjectboron; CAM assay; jellyfish collagen; organic-inorganic biohybrid; regenerative medicine; sol-gel; wool keratin
dc.titleOrganic-inorganic biohybrid films from wool-keratin/jellyfish-collagen/silica/boron via sol-gel reactions for soft tissue engineering applications
dc.typeArticle

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