The relationship between serum YKL-40 levels and arterial stiffness in patients with ankylosing spondylitis

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dc.contributor.authorTurkyilmaz, Kucukali A.
dc.contributor.authorDevrimsel, G.
dc.contributor.authorBeyazal, Serdaroglu M.
dc.contributor.authorKirbas, A.
dc.contributor.authorCicek, Y.
dc.contributor.authorCapkin, E.
dc.contributor.authorKarkucak, M.
dc.date.accessioned2025-01-27T20:39:21Z
dc.date.available2025-01-27T20:39:21Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Serum YKL-40 plays roles in inflammatory and vascular processes. Our aim was to evaluate serum YKL-40 levels in patients with ankylosing spondylitis (AS) and to investigate their potential relationship with arterial stiffness based on carotid-femoral pulse wave velocity (CF-PWV). Methods: Forty-three patients with AS and 41 healthy controls with no history or current signs of cardiovascular disease were included in the study. All patients were administered nonsteroidal anti-inflammatory drugs (NSAIDs), and none were prescribed anti-tumor necrosis factor agents. Serum YKL-40 levels were measured. CF-PWV and intima-media thickness of the common carotid artery (IMT-C) were evaluated. Results: The mean age of AS patients was 34.6 +/- 10.2 years and of controls was36.3 +/- 9.0 years. CF-PWV was significantly higher in AS patients than in controls (8.2 +/- 2.7 vs. 7.0 +/- 1.6 m/s, respectively; P=0.015). However, the IMT-C was not significantly different between AS patients and controls (0.6 +/- 0.3 vs. 0.5 +/- 0.2 mm, P=0.501). YKL-40 levels were significantly higher in AS patients than in controls (78.9 +/- 37.9 vs. 58.4 +/- 21.2 ng/mL, P=0.003) and were strongly correlated with CF-PWV (r=0.773, P<0.001) and IMT-C (r=0.548, P<0.001). A multiple linear regression analysis revealed that CF-PWV could be explained by serum YKL-40 levels and IMT-C (adjusted R-2 = 0.707, P=0.013 and P=0.001, respectively). AS patients with a higher disease activity score had higher YKL-40 levels, IMT-C, and CF-PWV than did those with a lower disease activity score (P<0.001, P=0.008, and P<0.001, respectively) Conclusion: AS patients had higher serum YKL-40 levels, CF-PWV, and IMT-C than did healthy controls. Additionally, there was an association between increased CF-PWV and serum YKL-40 levels. Therefore, we conclude that CF-PWV and YKL-40 levels may be used for early diagnosis of atherosclerosis in AS patients.
dc.identifier.endpage190
dc.identifier.issn0303-464X
dc.identifier.issue2
dc.identifier.pmid27680106
dc.identifier.startpage183
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23928
dc.identifier.volume42
dc.identifier.wosWOS:000405771400010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPublisaude-Edicoes Medicas Lda
dc.relation.ispartofActa Reumatologica Portuguesa
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAnkylosing spondylitis
dc.subjectArterial stiffness
dc.subjectCarotid-femoral pulse wave velocity
dc.subjectYKL-40 levels
dc.titleThe relationship between serum YKL-40 levels and arterial stiffness in patients with ankylosing spondylitis
dc.typeArticle

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