Understanding clinical outcomes and factors influencing mortality in intensive care unit patients with COVID-19-associated candidemia

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dc.authoridCascio, Antonio/0000-0002-1992-1796
dc.authoridUnver Ulusoy, Tulay/0000-0002-0172-2326
dc.authoridRashid, Naveed/0009-0002-9549-1289
dc.authoridBelitova, Maya/0000-0001-9575-1947
dc.authoridMoroti, Ruxandra/0000-0002-4453-3752
dc.authoridErdem, Hakan/0000-0002-6265-5227
dc.authoridEl-Sayed, Nagwa/0000-0001-6880-2147
dc.contributor.authorAydin, Selda
dc.contributor.authorMert, Ali
dc.contributor.authorYilmaz, Mesut
dc.contributor.authorAl Maslamani, Muna
dc.contributor.authorRahimi, Bilal Ahmad
dc.contributor.authorAyoade, Folusakin
dc.contributor.authorEl-Kholy, Amani
dc.date.accessioned2025-05-29T02:57:40Z
dc.date.available2025-05-29T02:57:40Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: During the COVID pandemic, research has shown an increase in candidemia cases following severe COVID infection and the identification of risk factors associated with candidemia. However, there is a lack of studies that specifically explore clinical outcomes and mortality rates related to candidemia after COVID infection. Objectives: The aim of this international study was to evaluate the clinical outcomes and identify factors influencing mortality in patients who developed candidemia during their COVID infection. Patients/Methods: This study included adult patients (18 years of age or older) admitted to the intensive care unit (ICU) and diagnosed with COVID-associated candidemia (CAC). The research was conducted through ID-IRI network and in collaboration with 34 medical centres across 18 countries retrospectively, spanning from the beginning of the COVID pandemic until December 2021. Results: A total of 293 patients diagnosed with CAC were included. The median age of the patients was 67, and 63% of them were male. The most common Candida species detected was C. albicans. The crude 30-day mortality rate was recorded at 62.4%. The logistic regression analysis identified several factors significantly impacting mortality, including age (odds ratio [OR] 1.04, 95% confidence interval [CI] 1.02-1.07, p < .0005), SOFA score (OR 1.307, 95% CI 1.17-1.45, p < .0005), invasive mechanical ventilation (OR 7.95, 95% CI 1.44-43.83, p < .017) and duration of mechanical ventilation (OR 0.98, 95% CI 0.96-0.99, p < .020). Conclusions: By recognising these prognostic factors, medical professionals can customise their treatment approaches to offer more targeted care, leading to improved patient outcomes and higher survival rates for individuals with COVID-associated candidemia.
dc.identifier.doi10.1111/myc.13687
dc.identifier.issn0933-7407
dc.identifier.issn1439-0507
dc.identifier.issue1
dc.identifier.pmid38214425
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/myc.13687
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30132
dc.identifier.volume67
dc.identifier.wosWOS:001153318300029
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofMycoses
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250529
dc.subjectcandidemia
dc.subjectCOVID-19
dc.subjectCOVID-19-associated candidemia
dc.subjectintensive care unit
dc.subjectmortality
dc.titleUnderstanding clinical outcomes and factors influencing mortality in intensive care unit patients with COVID-19-associated candidemia
dc.typeArticle

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