Protective Effects of Melatonin against Chronic Sodium Nitrite Exposure in Rats

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dc.contributor.authorUslu, Hamit
dc.contributor.authorUslu, Gözde Atila
dc.contributor.authorAdalı, Yasemen
dc.contributor.authorMakav, Mustafa
dc.contributor.authorGelen, Volkan
dc.date.accessioned2025-01-27T19:57:47Z
dc.date.available2025-01-27T19:57:47Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, anti-inflammatory effects melatonin (Mel) on liver and kidney damage induced by sodium nitrite (NaNO2) used as a food additive were investigated. The study groups were control group (C), NaNO2 group (NaNO2) and melatonin + NaNO2 group (Mel + NaNO2). The first group received dimethyl sulfoxide (DMSO) and the second and third groups received NaNO2 orally for twelve weeks. The third group received melatonin 2 hours before the administration of NaNO2. Administration of NaNO2 (80 mg/kg/day) for 12 weeks orally to rats increased serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) (P<0.001) and urea (P<0.01) levels. Interleukin 1-alpha (IL-1?) (P<0.05) and tumor necrosis factor alpha (TNF-?) (P<0.01, P<0.001 respectively) levels were found to be increased in NaNO2 group in liver and kidney homogenates. It was also determined that IL-6 (P<0.001) levels were increased in kidney tissue. On the other hand, it was also found that there was a decrease at the levels of serum AST (P<0.001), ALT, urea (P<0.05), liver IL-1?, TNF-? (P<0.01), and kidney TNF-?, IL-6 (P<0.05) in group given melatonin (500 ?g/kg/day) 2 hours before NaNO2. In addition, it was observed that there was less liver and kidney damage than NaNO2 group in the pathological examinations Mel + NaNO2 applied group. The present data demonstrate that melatonin administration has visible modulatory effects and can eliminate inflammation; moreover, it can prevent the increase in biochemical markers caused by chronic sodium nitrite administration
dc.identifier.endpage145
dc.identifier.issn1308-9323
dc.identifier.issn2149-1712
dc.identifier.issue3
dc.identifier.startpage139
dc.identifier.trdizinid333222
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/333222
dc.identifier.urihttps://hdl.handle.net/20.500.12428/19735
dc.identifier.volume33
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofFırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectBiyoloji
dc.subjectToksikoloji
dc.subjectBiyokimya ve Moleküler Biyoloji
dc.subjectVeterinerlik
dc.titleProtective Effects of Melatonin against Chronic Sodium Nitrite Exposure in Rats
dc.typeArticle

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