Antiproliferative Activity of Anthocyanins Pure Extracts from Mulberries and Raspberries on HeLa and A2780 Human Cancer Cell Lines

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dc.authoridRUGINA, Dumitrita Olivia/0000-0003-4881-3273
dc.authoridDiaconeasa, Zorita/0000-0002-5325-3859
dc.contributor.authorNistor, Madalina
dc.contributor.authorGhiman, Raluca
dc.contributor.authorAyvaz, Huseyin
dc.contributor.authorRugina, Dumitrita
dc.contributor.authorMada, Diana
dc.contributor.authorStanila, Andreea
dc.contributor.authorSocaciu, Carmen
dc.date.accessioned2025-01-27T20:16:42Z
dc.date.available2025-01-27T20:16:42Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractRed berries are important sources of bioactive compounds and they are known to provide unique health benefits. Lately, it has been proved that anthocyanins have health benefits against degenerative diseases such as cardiovascular disease, cancer or diabetes. Accordingly, the aim of this study was to characterize the anthocyanin content of anthocyanins pure extracts (APEs) obtained from raspberries (Rubus sp.) and mulberries (Morus sp.) and to evaluate their antiproliferative effect in vitro. Upon chromatographic analysis, three anthocyanins were identified in purified extracts of mulberries (M-APEs), with cyanidin-3-O-glucoside being more abundant. On the other hand, purified extracts of raspberries (R-APEs) contained 2 anthocyanins, both identified as cyanidinderivatives. The in vitro test demonstrated that APEs decreased the proliferation on both HeLa and A2780 human cancer cell lines in a dose dependent manner, demonstrating that these two different berries are both rich sources of anthocyanins and are able to exert antiproliferative proprieties toward cervical and ovarian cancer.
dc.description.sponsorshipExecutive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI) [16/01.10.2015, PN-II-RU-TE-2014-4-0944]
dc.description.sponsorshipThis work was financed by Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI) project number 16/01.10.2015,PN-II-RU-TE-2014-4-0944.
dc.identifier.doi10.15835/buasvmcn-fst:2017.0038
dc.identifier.endpage162
dc.identifier.issn2344-2344
dc.identifier.issn2344-5300
dc.identifier.issue2
dc.identifier.startpage156
dc.identifier.urihttps://doi.org/10.15835/buasvmcn-fst:2017.0038
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21356
dc.identifier.volume75
dc.identifier.wosWOS:000457209300006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherUniv Agricultural Sciences & Veterinary Medicine Cluj-Napoca
dc.relation.ispartofBulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca-Food Science and Technology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectanthocyanins
dc.subjectberries
dc.subjectcancer
dc.subjectHPLC
dc.titleAntiproliferative Activity of Anthocyanins Pure Extracts from Mulberries and Raspberries on HeLa and A2780 Human Cancer Cell Lines
dc.typeArticle

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