COPET study findings regarding the clinical relevance of biomass exposure as an etiotype in COPD

Basit Öğe Kaydı
dc.authorid0000-0003-0692-4784
dc.authorid0000-0002-0780-6176
dc.contributor.authorYazar, Esra Ertan
dc.contributor.authorDemirci, Nilgun
dc.contributor.authorYigitbas, Burcu Arpinar
dc.contributor.authorCalikoglu, Mukadder
dc.contributor.authorGulbas, Gazi
dc.contributor.authorTuran, Muzaffer Onur
dc.contributor.authorSahin, Hulya
dc.date.accessioned2026-02-03T12:02:49Z
dc.date.available2026-02-03T12:02:49Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: The finding that COPD can also develop in non-smokers has led to further investigations of etiologic causes other than smoking. This study evaluated the relationship between tobacco smoking and/or biomass-burning smoke exposure (BBS) and the demographic, clinical, and prognostic characteristics of individuals with COPD. Methods; A total of 1129 stable COPD patients from the COPET study were retrospectively analyzed. The patients were divided into three groups: the COPD-B group (n = 52), which included patients who were solely BBS; the COPD-C group (n = 634), which included patients who exclusively tobacco smoking; and the COPD-BC group (n = 443), which included patients with both BBS and tobacco smoking. Results: The average age of the patients was 65.8 +/- 9.1 years, and 87.4 % of them were men. In the COPD-B group, the following factors were significantly greater compared to the COPD-C and COPD-BC groups: age (p = 0.001), BMI (p = 0.001), percentage of female patients (p < 0.001), FEV1/FVC ratio (p = 0.014), eosinophil count (p < 0.001), ADO score (p < 0.001), and the proportion of patients with frequent exacerbations (p = 0.013). Thorax CT scans showed that the COPD-BC group had a greater incidence of bronchiectasis and emphysema than the COPD-B and COPD-C groups (p < 0.001). Conclusions: This study highlights significant clinical and radiological differences among COPD patients based on tobacco smoking and BBS, which may substantially impact COPD outcomes, including exacerbations and prognosis.
dc.identifier.doi10.1016/j.amjms.2025.07.001
dc.identifier.endpage370
dc.identifier.issn0002-9629
dc.identifier.issn1538-2990
dc.identifier.issue4
dc.identifier.pmid40645336
dc.identifier.startpage365
dc.identifier.urihttps://doi.org/10.1016/j.amjms.2025.07.001
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34881
dc.identifier.volume370
dc.identifier.wosWOS:001584477800010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofAmerican Journal of the Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectNon-smokers
dc.subjectBiomass
dc.subjectChronic obstructive pulmonary disease
dc.subjectEtiotypes
dc.subjectTaxonomy
dc.titleCOPET study findings regarding the clinical relevance of biomass exposure as an etiotype in COPD
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu