High frequency of chromosomal anomalies and a novel chromosomal insertion associated with infertility and recurrent miscarriages (reproductive failure) in West Turkey

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dc.contributor.authorSılan, Fatma
dc.contributor.authorYalcintepe, Sinem
dc.contributor.authorUysal, Digdem
dc.contributor.authorUrfali, Mine
dc.contributor.authorUludağ, Ahmet
dc.contributor.authorCosar, Emine
dc.contributor.authorGungor, Ayse Nur Cakir
dc.date.accessioned2025-01-27T19:06:13Z
dc.date.available2025-01-27T19:06:13Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractNumerical and/or structural chromosomal abnormalities may be a reason of high infertility rates and recurrent pregnancy losses (RPLs) in humans. Karyotype and karyogram profiles of patients with RPLs are presented in current results. A total of 722 patients; 161(44.5%) infertile and 200(55.5%) RPL couples were included in the study. Karyotype and structural chromosome analyses of both patient groups in Canakkale population were made between May 2011-December 2013, using peripheral lymphocyte cell culture and GTG banding technique. High frequency of chromosomal abnormalities(%7.45) were detected in 24 patients of the infertility group(n:322). 10 patients(42%) of this group(n:24) had numerical and 14 patients(58%) had balanced structural choromosomal abnormalities. A novel choromosomal insertion was found in an infertile male, one of the 22th choromosome was totally inserted in 9th choromosome [ins(9;22)(9pter-q12
dc.identifier.endpage148
dc.identifier.issn1529-9120
dc.identifier.issue1
dc.identifier.scopus2-s2.0-84920641639
dc.identifier.scopusqualityN/A
dc.identifier.startpage139
dc.identifier.urihttps://hdl.handle.net/20.500.12428/14190
dc.identifier.volume16
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherGene Therapy and Molecular Biology
dc.relation.ispartofGene Therapy and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250125
dc.subjectChromosome; Cytogenetics; Insertion; Inversion; Translocation
dc.titleHigh frequency of chromosomal anomalies and a novel chromosomal insertion associated with infertility and recurrent miscarriages (reproductive failure) in West Turkey
dc.typeArticle

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