The microbiological diagnosis of tuberculous meningitis: Results of Haydarpasa-1 study

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dc.contributor.authorErdem, H.
dc.contributor.authorOzturk-Engin, D.
dc.contributor.authorElaldi, N.
dc.contributor.authorGulsun, S.
dc.contributor.authorSengoz, G.
dc.contributor.authorCrisan, A.
dc.contributor.authorJohansen, I.S.
dc.date.accessioned2025-01-27T18:56:04Z
dc.date.available2025-01-27T18:56:04Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractWe aimed to provide data on the diagnosis of tuberculous meningitis (TBM) in this largest case series ever reported. The Haydarpasa-1 study involved patients with microbiologically confirmed TBM in Albania, Croatia, Denmark, Egypt, France, Hungary, Iraq, Italy, Macedonia, Romania, Serbia, Slovenia, Syria and Turkey between 2000 and 2012. A positive culture, PCR or Ehrlich-Ziehl-Neelsen staining (EZNs) from the cerebrospinal fluid (CSF) was mandatory for inclusion of meningitis patients. A total of 506 TBM patients were included. The sensitivities of the tests were as follows: interferon-? release assay (Quantiferon TB gold in tube) 90.2%, automated culture systems (ACS) 81.8%, Löwenstein Jensen medium (L-J) 72.7%, adenosine deaminase (ADA) 29.9% and EZNs 27.3%. CSF-ACS was superior to CSF L-J culture and CSF-PCR (p <0.05 for both). Accordingly, CSF L-J culture was superior to CSF-PCR (p <0.05). Combination of L-J and ACS was superior to using these tests alone (p <0.05). There were poor and inverse agreements between EZNs and L-J culture (? = -0.189); ACS and L-J culture (? = -0.172) (p <0.05 for both). Fair and inverse agreement was detected for CSF-ADA and CSF-PCR (? = -0.299, p <0.05). Diagnostic accuracy of TBM was increased when both ACS and L-J cultures were used together. Non-culture tests contributed to TBM diagnosis to a degree. However, due to the delays in the diagnosis with any of the cultures, combined use of non-culture tests appears to contribute early diagnosis. Hence, the diagnostic approach to TBM should be individualized according to the technical capacities of medical institutions particularly in those with poor resources. © 2013 European Society of Clinical Microbiology and Infectious Diseases.
dc.identifier.doi10.1111/1469-0691.12478
dc.identifier.endpageO608
dc.identifier.issn1198-743X
dc.identifier.issue10
dc.identifier.pmid24849547
dc.identifier.scopus2-s2.0-84913605718
dc.identifier.scopusqualityQ1
dc.identifier.startpageO600
dc.identifier.urihttps://doi.org/10.1111/1469-0691.12478
dc.identifier.urihttps://hdl.handle.net/20.500.12428/12844
dc.identifier.volume20
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBlackwell Publishing Ltd
dc.relation.ispartofClinical Microbiology and Infection
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250125
dc.subjectPCR; Culture; Diagnosis; Meningitis; Tuberculosis
dc.titleThe microbiological diagnosis of tuberculous meningitis: Results of Haydarpasa-1 study
dc.typeArticle

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