PLASMA LEVELS OF NESFATIN-1 IN PATIENTS WITH POLYCYSTIC OVARY SYDROME

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dc.authoridAsik, mehmet/0000-0002-0716-0221
dc.contributor.authorBinnetoglu, Emine
dc.contributor.authorErbag, Gokhan
dc.contributor.authorGencer, Meryem
dc.contributor.authorTurkon, Hakan
dc.contributor.authorAsik, Mehmet
dc.contributor.authorGunes, Fahri
dc.contributor.authorSen, Hacer
dc.date.accessioned2025-01-27T20:47:45Z
dc.date.available2025-01-27T20:47:45Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction. Polycycstic ovary syndrome (PCOS) is an important disorder in women of reproductive age which is characterised with menstrual dysfunction, anovulation and hyperandrogenism. 5-10% of the female population affected by this syndrome. Nesfatin-1 is a new anorexigenic hormone which is expressed from several regions of hypothalamus and peripheral tissues. Nesfatin-1 is related with obesity, insulin resistance and appetite. We aimed to evaluated the nesfatin-1 levels in patients with PCOS. Material and methods: Sixty-five patients (37 patients with PCOS and 28 healthy control subjects) were enrolled in the study. We included newly diagnosed patients with PCOS in our study. Diagnosis of PCOS was based on the 2003 ESHREIASRM diagnostic criteria. Results: The patients with PCOS and controls were similar in terms of mean age body mass index (BMI), waist/hip (W/H) ratio and homeostasis model assessment-insulin resistance (HOMA-IR) index. Plasma Nesfatin-1 levels were similar between groups. There was no correlation between plasma Nesfatin-1 levels and other parameters. Conclusion: In conclusion nesfatin-1 may be play important role in glucose metabolism and insulin resistance. In this study due to the absence of insulin resistance in PCOS patients, levels of Nesfatin-1 were similar with control group. Nesfatin levels were associated with glucose metabolism, but further studies are needed in this regard.
dc.identifier.endpage204
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue1
dc.identifier.startpage201
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25035
dc.identifier.volume30
dc.identifier.wosWOS:000335937700032
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherCarbone Editore
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectNesfatin-1
dc.subjectinsulin resistance
dc.subjectpolycystic Ovary Syndrome
dc.titlePLASMA LEVELS OF NESFATIN-1 IN PATIENTS WITH POLYCYSTIC OVARY SYDROME
dc.typeArticle

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