Plasma levels of Nesfatin-1 in patients with polycystic ovary sydrome

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dc.contributor.authorBinneto?lu, Emine
dc.contributor.authorErba?, Gökhan
dc.contributor.authorGencer, Meryem
dc.contributor.authorTurkön, Hakan
dc.contributor.authorAşik, Mehmet
dc.contributor.authorGüneş, Fahri
dc.contributor.authorŞen, Hacer
dc.date.accessioned2025-01-27T19:05:52Z
dc.date.available2025-01-27T19:05:52Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction: Polycycstic ovary syndrome (PCOS) is an important disorder in women of reproductive age which is characterised with menstrual dysfunction, anovulation and hyperandrogenism. 5-10% of the female population affected by this syndrome. Nesfatin-1 is a new anorexigenic hormone which is expressed from several regions of hypothalamus and peripheral tissues. Nesfatin-1 is related with obesity, insulin resistance and appetite. We aimed to evaluated the nesfatin-1 levels in patients with PCOS. Material and methods: Sixty-five patients (37 patients with PCOS and 28 healthy control subjects) were enrolled in the study. We included newly diagnosed patients with PCOS in our study. Diagnosis of PCOS was based on the 2003 ESHRE/ASRM diagnostic criteria. Results: The patients with PCOS and controls were similar in terms of mean age body mass index (BMI), waist/hip (W/H) ratio and homeostasis model assessment-insulin resistance (HOMA-IR) index. Plasma Nesfatin-1 levels were similar between groups. There was no correlation between plasma Nesfatin-1 levels and other parameters. Conclusion: In conclusion nesfatin-1 may be play important role in glucose metabolism and insulin resistance. In this study due to the absence of insulin resistance in PCOS patients, levels of Nesfatin -1 were similar with control group. Nesfatin levels were associated with glucose metabolism, but further studies are needed in this regard.
dc.identifier.endpage204
dc.identifier.issn0393-6384
dc.identifier.issue1
dc.identifier.scopus2-s2.0-84896899515
dc.identifier.scopusqualityN/A
dc.identifier.startpage201
dc.identifier.urihttps://hdl.handle.net/20.500.12428/14017
dc.identifier.volume30
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherActa Medica Mediterranea
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250125
dc.subjectInsulin resistance; Nesfatin-1; Polycystic ovary syndrome
dc.titlePlasma levels of Nesfatin-1 in patients with polycystic ovary sydrome
dc.typeArticle

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