Detection of fetal keratin with high molecular weight cytokeratin immunostaining in lung biopsy material from a patient with amniotic fluid embolism

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dc.contributor.authorHacivelioglu, Servet
dc.contributor.authorOguzalp, Huseyin
dc.contributor.authorMuratli, Asli
dc.contributor.authorAsgun, Fatih
dc.contributor.authorKirilmaz, Bahadir
dc.contributor.authorOmur, Dilek
dc.date.accessioned2025-01-27T19:04:18Z
dc.date.available2025-01-27T19:04:18Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAmniotic fluid embolism (AFE) is a rare and fatal disorder in which the diagnosis can be challenging for clinicians and pathologists. A healthy 36-year-old woman (gravida 4, para 2) was admitted for delivery in the 40th week of gestation. At the fifth minute following birth, during expulsion of the placenta, the patient suddenly collapsed with bradycardia, shallow respiration, and loss of consciousness. After evaluation, an emergent pulmonary embolectomy for acute thrombo-embolism was performed, however the patient could not be weaned from cardiopulmonary bypass, and died of severe right ventricular dysfunction following the operation. Microscopic examination of the biopsy material detected clearly visible fetal epithelial squames inside pulmonary vessels, both with routine hematoxylin-eosin (HE) staining and immunostaining for high molecular weight cytokeratin (HMW-CK). The diagnosis of amniotic fluid embolism (AFE) was made, which was confirmed as the cause of death. We show that HMW-CK staining can be a useful means of detecting amniotic fluid-derived fetal keratin within alveolar tissue. We suggest that this technique, used in addition to HE staining and in combination with sudden-onset clinical findings, may increase the accuracy of diagnosis in AFE.
dc.identifier.endpage100
dc.identifier.issn1301-0883
dc.identifier.issue2
dc.identifier.scopus2-s2.0-84879747474
dc.identifier.scopusqualityQ4
dc.identifier.startpage97
dc.identifier.urihttps://hdl.handle.net/20.500.12428/13903
dc.identifier.volume18
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofEastern Journal of Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250125
dc.subjectAmniotic fluid embolism; Cardiovascular collapse; Cytokeratin; High molecular weight cytokeratin; HMW-CK
dc.titleDetection of fetal keratin with high molecular weight cytokeratin immunostaining in lung biopsy material from a patient with amniotic fluid embolism
dc.typeArticle

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