Effect of Resveratrol in Acute Hypoxic Pulmonary Vasoconstriction in Isolated Lamb Pulmonary Arteries and Veins

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dc.authoridSılan, Coşkun/0000-0002-8352-6571
dc.contributor.authorSılan, Coşkun
dc.contributor.authorKuscuoglu, Evren
dc.contributor.authorUzun, Oezge
dc.contributor.authorBalbay, Oener
dc.date.accessioned2025-01-27T20:58:23Z
dc.date.available2025-01-27T20:58:23Z
dc.date.issued2009
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractResveratrol (RSV) is a natural phytoalexin with many biological effects, including antioxidant, anti-platelet, anti-atherogenic, anti-inflamatory, estrogenic properties, immunomodulation and chemoprevention. In the cardiovascular system, it has been shown to cause relaxation of vascular smooth muscle, and reports indicate that RSV induces vasodilatory effects in several vascular beds by acting in endothelium dependent and independent manners. The aim of the study was to determine the role of RSV on hypoxia induced vasoconstriction in precontracted isolated pulmonary arteries and veins. Isolated lamb pulmonary vessels were suspended in an organ bath filled with Krebs Heinseleit solution and isolated contractions were recorded continuously via an isometric transducer connected to a computerized polygraph system. The solution was aerated with room air or a gas mixture of 95% N-2 + 5% CO2 (hypoxic). The oxygen concentration of the bathing medium was measured using an oxygen electrode. Serotonin (5-HT)(10(-5) M) for arteries and U46619, a thromboxane analog (TXA2) for veins, were used as pre contractile agents. Our results showed that in the presence of RSV (20 mu M), hypoxia induced pulmonary vasoconstriction decreased in pulmonary veins pre contracted with U46619, but not in pulmonary arteries pre contracted with 5-HT.
dc.identifier.endpage845
dc.identifier.issn1300-6045
dc.identifier.issue6
dc.identifier.startpage841
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26693
dc.identifier.volume15
dc.identifier.wosWOS:000274088000004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisi
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subject5-HT
dc.subjectHypoxia
dc.subjectPulmonary vasoconstriction
dc.subjectResveratrol
dc.subjectU46619
dc.titleEffect of Resveratrol in Acute Hypoxic Pulmonary Vasoconstriction in Isolated Lamb Pulmonary Arteries and Veins
dc.typeArticle

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