The Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model

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dc.contributor.authorTokmak, Mehmet
dc.contributor.authorSehıtoglu, Muserref Hilal
dc.contributor.authorYuksel, Yasemin
dc.contributor.authorGüven, Mustafa
dc.contributor.authorAkman, Tarık
dc.contributor.authorAras, Adem Bozkurt
dc.contributor.authorYaka, Umut
dc.date.accessioned2025-01-27T20:01:26Z
dc.date.available2025-01-27T20:01:26Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAIm: In the relevant literature, there is no experimental study that investigated the axon protective effects of syringic acid- a polyphenol compound- with an anti-oxidant capacity on ischemia/reperfusion injury. mATERIAl and mEThODS: The rats were randomly divided into four groups: Control group (no medication or surgical procedure), Sham group, Syringic acid group, and Methyprednisolone (MP) Group. Ischemia was achieved by abdominal aorta clamping and all animals were sacrificed 24 hours after ischemia. Harvested sciatic nerve segments were investigated histopathologically and for tissue biochemistry. RESUlTS: Ischemic fiber degeneration scores were found significantly lower in syringic acid and MP groups than sham group. Additionally, apoptosis-related cysteine peptidase caspase-3 immunostaining scores were lower in syringic acid and MP groups. Biochemically, superoxide dismutase and nuclear respiratory factor 1 values were significantly higher in syringic acid group compared to those of control and sham groups while malondialdehyde levels were significantly lower in the syringic acid group. CONClUSION: Syringic acid reduces oxidative stress and axonal degeneration in rat sciatic nerve after ischemia/reperfusion injury. Therefore, syringic acid may play a role in the treatment of peripheral nerve injuries due to ischemia/reperfusion.
dc.identifier.endpage132
dc.identifier.issn1019-5149
dc.identifier.issue1
dc.identifier.startpage124
dc.identifier.trdizinid217728
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/217728
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20091
dc.identifier.volume27
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectBiyoloji
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectNörolojik Bilimler
dc.titleThe Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model
dc.typeArticle

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