Electrochemical investigation of isoniazid on poly (p-aminobenzene sulfonic acid) film modified glassy carbon electrode

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dc.contributor.authorDemirbilek, Esra
dc.contributor.authorSaglikoglu, Gulsen
dc.contributor.authorYilmaz, Selehattin
dc.date.accessioned2025-01-27T19:04:07Z
dc.date.available2025-01-27T19:04:07Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIsoniazid is a tuberculostatic agent effective active compound. A glassy carbon electrode (GCE) was modified with an electropolymerized film of p-aminobenzene sulfonic acid (p-ABSA) in phosphate buffer solution (PBS). The electrochemical properties of isoniazid on modified electrode were studied by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The polymer film-modified electrode was used to electrochemically detect isoniazid. The polymer film had excellent electrocatalytic activity for the oxidation of isoniazid. A linear calibration curve for DPV analysis was constructed in the isoniazid concentration range 2x10-5- 1x10-4 mol L-1. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 3.05x10-6 and 1.01x10-5 mol L-1 respectively. Isoniazid was determined in tablet dosage form. The proposed method exhibits good recovery and reproducibility. The mechanisms of electropolymerization were also suggested. © 2015 The Authors.
dc.identifier.endpage4438
dc.identifier.issn1452-3981
dc.identifier.issue5
dc.identifier.scopus2-s2.0-84929410249
dc.identifier.scopusqualityQ3
dc.identifier.startpage4428
dc.identifier.urihttps://hdl.handle.net/20.500.12428/13816
dc.identifier.volume10
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElectrochemical Science Group
dc.relation.ispartofInternational Journal of Electrochemical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250125
dc.subjectDetermination of isoniazid; Electrocatalytic-oxidation; Electropolymerization; Modified-glassy carbon electrode; p-Aminobenzene sulfonic acid
dc.titleElectrochemical investigation of isoniazid on poly (p-aminobenzene sulfonic acid) film modified glassy carbon electrode
dc.typeArticle

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