A Mild Type Propofol Infusion Syndrome Presentation in Critical Care

Propofol infusion syndrome (PRIS) is a rare but fatal disease. Itwas occured mostly after high dose of propofol infusions for longtimes. Metabolic acidosis, hypotension, myoglobinuria, elevatedmuscle and liver enzymes, cardiac arrhythmias, cardiac arrest arecommon manifestations of the syndrome. This case report concludeda mild type of PRIS which was presented after low dose(25–50 mcg/kg/min) infusion for long time. In this case significantmetabolic acidosis, hypotension and arrhythmias were not detectedduring drug infusion. Syndrome was manifested with only significantlyelevated AST, ALT, CK, CKMB, LDH levels. Persistenceof these findings during propofol infusion without patient’s furtherclinical impairments defined as mild type of PRIS. In addition, theimprovements in the biochemical parameters deteriorated afterthe drug was discontinued proved the validity of our diagnosis.