An amino acid, L-Glutamic acid-based metal-organic frameworks and their antibacterial, blood compatibility, biocompatibility, and sensor properties

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dc.authoridCan, Mehmet / 0000-0002-5993-206X
dc.authoridDemirci, Şahin / 0000-0001-7083-1481
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorCan, Mehmet
dc.contributor.authorDemirci, Şahin
dc.contributor.authorSunol, Aydın K.
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:59:40Z
dc.date.available2025-01-27T20:59:40Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, metal-organic frameworks (MOFs) based on L-Glutamic acid (L-Glu), a natural amino acid as organic linker and Co (II), Ni (II), and Cu (II) metal ions were used in construction with 37.1 +/- 5.3%, 41.4 +/- 6.1%, 49.2 +/- 4.9% yields, respectively in ethanol under reflux. The prepared L-Glu-M (M: Co(II), Ni(II), and Cu (II)) MOFs were characterized in terms of their porosity, optical, thermal, electrical, and structural properties. Correspondingly, 102.1 m2/g, 83.7 m2/g, and 71.0 m2/g specific surface areas and 2.72 cm3/g, 0.46 cm3/g, and 0.07 cm3/g pore volumes were measured for L-Glu-based Co, Ni, and Cu MOFs. Moreover, the antimicrobial studies of L-Glu-M MOFs on Escherichia coil ATCC 8739, as gram-negative, and Staphylococcus aureus ATCC 6538 as gram-positive bacteria revealed that the highest inhibition zones with 42 +/- 2 mm and 44 +/- 1 mm were observed for L-Glu-Co MOFs. The hemolysis induction of L-Glu-M MOFs was evaluated, except L-Glu-Cu that induced 8.3 +/- 0.4% hemolysis, and the hemolytic characters of other MOF preparations were found to reside in safety margins possessing <= 4% hemolysis ratios. The blood clotting index of L-Glu-M MOFs were measured as 87.4 + 6.3% (Co(II)), 91.8 +/- 10.1% (Ni(II)), and 95.7 +/- 4.8% (Cu(II)) with neglectable interference to clotting mechanisms. Cytocompatibility of L-Glu-based MOFs were demonstrated that all MOF preparations with 25 mu g/mL concentrations maintained approximately 90% cell viabilities. Furthermore, Glu-based MOFs were demonstrated to possess sensory properties for NH3 vapor and could be employed in at least five cycles of repeated use. Therefore, L-Glu-M based MOFs can provide useful avenues in material science for a variety of biomedical and industrial applications.
dc.description.sponsorshipYildiz Yildirim from Kaleseram R&D Ctr, Canakkale, Turkey
dc.description.sponsorshipThe support from Yildiz Yildirim from Kaleseram R&D Ctr, Canakkale, Turkey, for repetition of some of the XRD experiments is greatly appreciated.
dc.identifier.doi10.1016/j.micromeso.2020.110533
dc.identifier.issn1387-1811
dc.identifier.issn1873-3093
dc.identifier.scopus2-s2.0-85089810591
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.micromeso.2020.110533
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26779
dc.identifier.volume309
dc.identifier.wosWOS:000577314900006
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofMicroporous and Mesoporous Materials
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectL-Glutamic acid MOF
dc.subjectAmino acid MOF
dc.subjectNH3 sensor
dc.subjectBlood & biocompatible porous materials
dc.subjectAntibacterial framework
dc.titleAn amino acid, L-Glutamic acid-based metal-organic frameworks and their antibacterial, blood compatibility, biocompatibility, and sensor properties
dc.typeArticle

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