The Antibody Response to Endoplasmic Reticulum Stress in Hashimoto's Thyroiditis

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dc.authoridsahin, mustafa/0000-0002-4718-0083
dc.contributor.authorAsik, Mehmet
dc.contributor.authorSahin, Mustafa
dc.contributor.authorAnaforoglu, Inan
dc.contributor.authorArikan, Serap
dc.contributor.authorHaydardedeoglu, Filiz Eksi
dc.contributor.authorErtugrul, Taner Derun
dc.contributor.authorTutuncu, Neslihan Bascil
dc.date.accessioned2025-01-27T21:20:01Z
dc.date.available2025-01-27T21:20:01Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: We aimed to investigate the presence of antibodies (Anti-BIP) against binding immunoglobulin protein (BIP), an endoplasmic reticulum (ER) chaperone with immune modulator and anti-apoptotic effects in Hashimoto's thyroiditis (HT) patients. Material and Method: We included sixty-two autoimmune thyroiditis patients, 20 with euthyroid autoimmune thyroiditis, 27 with subclinical hypothyroidism and 15 with hypothyroid, and a control group of 37 healthy subjects. Results: No statistically significant difference was determined in anti-BIP levels among the HT subgroups or in comparison with the control group (p= 0.889). Discussion: Although BIP activation has been shown in vitro in thyroid cells, no difference was determined in our study in anti-BIP levels between the HT patient subgroups and the control group. This suggests that antibodies developing against BIP through apoptosis and/or T cell response are either not related to HT or at levels that cannot be determined by measuring serum.
dc.identifier.doi10.4274/Tjem.2151
dc.identifier.endpage56
dc.identifier.issn1301-2193
dc.identifier.issue3
dc.identifier.startpage53
dc.identifier.urihttps://doi.org/10.4274/Tjem.2151
dc.identifier.urihttps://hdl.handle.net/20.500.12428/28798
dc.identifier.volume17
dc.identifier.wosWOS:000217336100002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherGalenos Yayincilik
dc.relation.ispartofTurkish Journal of Endocrinology and Metabolism
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectHashimoto's thyroiditis
dc.subjectAnti-BIP
dc.subjectBIP
dc.subjectapoptosis
dc.subjectendoplasmic reticulum stress
dc.titleThe Antibody Response to Endoplasmic Reticulum Stress in Hashimoto's Thyroiditis
dc.typeArticle

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