Ozone vs Melatonin: The Therapeutic Effects In Alcoholic Liver Disease

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dc.contributor.authorEroğlu, Hüseyin Avni
dc.contributor.authorMakav, Mustafa
dc.contributor.authorGüvend, Gülname Fındık
dc.contributor.authorBüyük, Başak
dc.contributor.authorAdalı, Yasemen
dc.date.accessioned2025-01-27T19:34:45Z
dc.date.available2025-01-27T19:34:45Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Alcoholic liver disease (ALD) is a worldwide health problem.Ozone and melatonin areagents that are widely used for their antioxidant properties in medical therapies.In this study, we aimedto evaluate the use of ozone and melatoninin ALD.Materials and Methods: Forty-eight rats were used, and ethanol, melatonin, and ozone wereadministrated. Histopathological evaluation was performed and activities of alanine aminotransferase(ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT) total antioxidant status(TAS), total oxidant status (TOS), and malondialdehyde (MDA)were determined in the blood samples,while TAS, TOS, and MDA parameters were measured in the liver tissue samples.Results: There were statistically significant differences between the studied groups concerning ALT,AST activities and TAS, TOS, and MDA levels. Vascular congestion, hepatocyte damage, periportalinflammation, and microvesicular steatosis were detected inthe alcohol-induced toxicity group.Conclusions: In the light of histopathological findings, we can claim that melatonin and ozoneadministrations are beneficial for alcohol-induced hepatotoxicity. However, ozone application issuperior to melatonin.
dc.identifier.doi10.35440/hutfd.649302
dc.identifier.endpage139
dc.identifier.issn1304-9623
dc.identifier.issn1309-4025
dc.identifier.issue1
dc.identifier.startpage133
dc.identifier.trdizinid449916
dc.identifier.urihttps://doi.org/10.35440/hutfd.649302
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/449916
dc.identifier.urihttps://hdl.handle.net/20.500.12428/16694
dc.identifier.volume17
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofHarran Üniversitesi Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectTamamlayıcı ve Entegre Tıp
dc.subjectGenel ve Dahili Tıp
dc.subjectGastroenteroloji ve Hepatoloji
dc.titleOzone vs Melatonin: The Therapeutic Effects In Alcoholic Liver Disease
dc.typeArticle

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