Plasma Amino Acid Levels in Obese Adolescents: A Case-Control Study and the Review of the Literature

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dc.contributor.authorSoylu Ustkoyuncu, Pembe
dc.contributor.authorDoğan, Durmuş
dc.contributor.authorKardas, Fatih
dc.contributor.authorKendirci, Mustafa
dc.contributor.authorDündar, Mehmet Akif
dc.contributor.authorCanpolat, Arife
dc.contributor.authorAltuner Torun, Yasemin
dc.date.accessioned2026-02-03T11:50:14Z
dc.date.available2026-02-03T11:50:14Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractOptimal balance among amino acids in the circulation is important for body homeostasis. This study aims to evaluate and define the amino acids associated with obesity and insulin resistance. Fifty obese and 42 healthy adolescents aged 10-18 years were included in this study. Fasting plasma glucose, liver enzymes, thyroid function tests, insulin, and lipid levels were studied as routine laboratory examinations, and 26 plasma amino acids were studied as specific laboratory examinations. Isoleucine, leucine, lysine, tryptophan, glutamate, tyrosine, phenylalanine, alanine, methionine, argininosuccinic acid, histidine and valine were significantly higher in patients with obesity. Asparagine and citrulline levels were lower in patients with insulin resistance. The metabolic pathways of various amino acids are significantly impaired in obesity. Plasma concentrations of essential, non-essential, branched-chain, and aromatic amino acids were elevated in this study.
dc.identifier.doi10.4274/jpea.2025.436
dc.identifier.endpage80
dc.identifier.issn2718-0875
dc.identifier.issue2
dc.identifier.startpage74
dc.identifier.trdizinid1326575
dc.identifier.urihttps://doi.org/10.4274/jpea.2025.436
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1326575
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34050
dc.identifier.volume6
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofThe journal of pediatric academy (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR_20260130
dc.subjectObesity
dc.subjectadolescent
dc.subjectAmino acids
dc.titlePlasma Amino Acid Levels in Obese Adolescents: A Case-Control Study and the Review of the Literature
dc.typeArticle

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