Left Atrial Appendage Function in Mitral Stenosis: Is It Determined by Cardiac Rhythm?

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dc.authoridTURK, UGUR ONSEL/0000-0001-6348-6616
dc.authoridErcan, Ertugrul/0000-0003-0480-4738
dc.contributor.authorSaygi, Serkan
dc.contributor.authorTurk, Ugur Onsel
dc.contributor.authorAlioglu, Emin
dc.contributor.authorKirilmaz, Bahadir
dc.contributor.authorTengiz, Istemihan
dc.contributor.authorTuzun, Nurullah
dc.contributor.authorErcan, Ertugrul
dc.date.accessioned2025-01-27T20:59:55Z
dc.date.available2025-01-27T20:59:55Z
dc.date.issued2011
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground and aim of the study: The left atrial appendage (LAA) is a common source of cardiac thrombus formation associated with systemic embolism in patients with mitral stenosis (MS). Low flow velocities in the LAA are important factors in the development of thrombosis. Whilst oral anticoagulant therapy is used routinely in MS with atrial fibrillation (AF), the characteristics of LAA contractile functions and the protective role of oral anticoagulant treatment in patients with MS in sinus rhythm (SR) are unclear. The study aim was to compare LAA contractile functions in patients with MS who were either in SR or had AF. Methods: The study population comprised 51 patients with MS, who had undergone both standard transthoracic and transesophageal echocardiography. The patients were allocated to two groups, according to the presence of AF or SR. Ten healthy, gender-matched subjects were included in the study as a control group. Results: Except for age, the characteristics of the groups were similar. In patients with SR and AF, the LAA contractile functions were significantly lower than in controls. While the LAA contractile functions of the SR group were significantly lower than the AF group (LAA emptying/filling velocity: 26 +/- 7/24 +/- 8 versus 19 +/- 5/17 +/- 5 cm/s; p = 0.002 and p = 0.001, respectively, LAA maximum/minimum area: 5.4 +/- 1.2/3.2 +/- 0.9 versus 6.2 +/- 1.1/3.7 +/- 0.8 cm(2), p = 0.02 and p =0.02, respectively), no statistically significant differences were observed between patients in SR with mitral valve area (MVA) <= 1.5 cm(2) and patients in AF. Four SR patients (13%) and six AF patients (27%) had LAA thrombus. A strong correlation was observed between the MVA and LAA peak emptying/filling velocity in patients with MS in SR (r = 0.739, p = 0.0001 and r = 0.728, p = 0.0001, respectively). Conclusion: The study results showed that LAA contractile function is diminished in patients with moderate-severe MS in SR, and to a similar degree as patients in AF. It was concluded that patients with moderate-severe MS in SR have a higher risk for thromboembolic events than MS patients in AF.
dc.identifier.endpage424
dc.identifier.issn0966-8519
dc.identifier.issue4
dc.identifier.pmid21863655
dc.identifier.startpage417
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26877
dc.identifier.volume20
dc.identifier.wosWOS:000293668200009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherI C R Publishers
dc.relation.ispartofJournal of Heart Valve Disease
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectSpontaneous Echo Contrast
dc.subjectTransesophageal Echocardiography
dc.subjectSinus Rhythm
dc.subjectValve
dc.titleLeft Atrial Appendage Function in Mitral Stenosis: Is It Determined by Cardiac Rhythm?
dc.typeArticle

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