A proton magnetic resonance spectroscopic study in juvenile absence epilepsy in early stages

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dc.authoridcanbaz kabay, sibel/0000-0003-4808-2191
dc.contributor.authorKabay, Sibel Canbaz
dc.contributor.authorGumustas, Oguzhan Guven
dc.contributor.authorKaraman, Handan Ozisik
dc.contributor.authorOzden, Hilmi
dc.contributor.authorErdinc, Oguz
dc.date.accessioned2025-01-27T20:31:52Z
dc.date.available2025-01-27T20:31:52Z
dc.date.issued2010
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: The aim of this study to evaluate the hippocampal, frontal and thalamic lobe functions in the early stage of the juvenile absence epilepsy (JAE) by magnetic resonance proton spectroscopy (MRS). Method: Fourteen patients with juvenile absence epilepsy with typical absence seizures and 10 healthy volunteer controls were included in this study. The diagnosis of the patients was in accordance with EEG findings and seizure semiology. All patients had minimum twice EEG recordings and all had typical 3-Hz generalized spike and slow-wave discharges at least on one EEG. All patients had bilateral MRS of frontal, thalamic and hippocampal regions and NAA, NAA/Cr, NAA/Cho, NAA/Cho + Cr levels were detected. Results: The mean age was 14.9 +/- 2.05 and 14.5 +/- 1.7 of the JAE patients and control subjects, respectively. Mean seizure onset duration were 2.3 +/- 0.9 years. In patient group the frontal, thalamic and hippocampal NAA/Cr ratios were 1.65, 1.78, 1.47 in right and 1.75, 1.90, 1.42 in left, respectively. While in the control group NAA/Cr ratios were 1.64, 2.42, 1.57 in right and 1.83, 2.44, 1.47 in left, respectively. There weren't any difference in frontal and hippocampal regions, but the bilateral thalamic NAA, NAA/Cr ratios of the patients were significantly lower than control group even in early stages of the disease. Conclusion: The observed reductions in NAA levels and NAA/Cr ratios of bilateral thalamic regions are consistent with epilepsy related excitoxicity as a possible underlying mechanism even in early stage of JAE. However, we believe that to generalize the results of our study a prospective multicenter study is required. (C) 2009 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.ejpn.2009.06.004
dc.identifier.endpage228
dc.identifier.issn1090-3798
dc.identifier.issn1532-2130
dc.identifier.issue3
dc.identifier.pmid19616977
dc.identifier.startpage224
dc.identifier.urihttps://doi.org/10.1016/j.ejpn.2009.06.004
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23290
dc.identifier.volume14
dc.identifier.wosWOS:000277744600005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofEuropean Journal of Paediatric Neurology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectJuvenile absence epilepsy
dc.subjectProton magnetic resonance spectroscopy
dc.subjectBrain
dc.subjectSeizures
dc.titleA proton magnetic resonance spectroscopic study in juvenile absence epilepsy in early stages
dc.typeArticle

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